山西医科大学学报2026，Vol.57Issue(5)：548-554,7.DOI:10.13753/j.issn.1007-6611.2026.05.006
中国中老年人锥度指数与衰弱风险的关联性
Association between conicity index and frailty in Chinese middle and old-aged adults
摘要
Abstract
Objective To analyze the relationship between conicity index and the risk of frailty occurrence,and clarify its predictive capacity for frailty,providing a theoretical basis for early frailty prevention and formulation of frailty management strategies.Methods Based on data from the China Health and Retirement Longitudinal Study(CHARLS),Cox proportional hazards regression models were employed to examine the association between conicity index and the risk of frailty incidence.Restricted cubic splines(RCS)were utilized to explore potential non-linear dose-response relationships between these variables.The predictive performance of conicity index for frailty was evaluated using receiver operating characteristic(ROC)curves and time-dependent ROC analysis.Results In fully adjusted Cox regression model,each 0.1-unit increase in conicity index was associated with a 14.0%elevated risk of frailty(HR=1.140,95%CI 1.086-1.196,P<0.001).When conicity index was stratified into tertiles,compared with the lowest tertile,the highest tertile of conicity index demonstrated a 27.1%increased risk of frailty(HR=1.271,95%CI 1.138-1.420,P<0.001).A significant trend test showed that the risk of frailty increased with elevated tertile levels of conicity index(Ptrend<0.001).RCS analysis revealed a J-shaped nonlinear relationship between conicity index and frailty incidence risk(Poverall<0.001;Pnon-linear=0.001),and the risk of frailty rose rapidly when conicity index exceeded 1.2.ROC and time-dependent ROC analyses results demonstrated that conicity index had the best predictive performance for frailty(AUC=0.600,95%CI 0.587-0.613)compared with body mass index(AUC=0.525,95%CI 0.512-0.538)and waist circumference(AUC=0.550,95%CI 0.537-0.562).Moreover,the predictive ability of conicity index for frailty increased gradually with increasing follow-up years.Conclusion Conicity index is positively associated with the frailty among Chinese middle and old-aged adults,and it may serve as a potentially effective indicator for frailty prevention and management.关键词
锥度指数/衰弱/中老年人/CHARLS/纵向研究/预测性能Key words
conicity index/frailty/middle and old-aged adults/CHARLS/longitudinal study/predictive performance分类
医药卫生引用本文复制引用
杨玉玲,荆晓欢,杨秀娟,周立业..中国中老年人锥度指数与衰弱风险的关联性[J].山西医科大学学报,2026,57(5):548-554,7.基金项目
国家自然科学基金项目(32301421) （32301421）
