实用心脑肺血管病杂志2026，Vol.34Issue(7)：72-77,6.DOI:10.12114/j.issn.1008-5971.2026.00.161
动脉粥样硬化患者tRF-His-GTG-037表达水平及其与血管平滑肌细胞表型转化标志物的关系研究
Expression Level of tRF-His-GTG-037 and Its Relationship with Markers of Vascular Smooth Muscle Cells Phenotypic Transition in Patients with Atherosclerosis
摘要
Abstract
Objective To investigate the expression level of tRF-His-GTG-037 and its relationship with markers of vascular smooth muscle cells(VSMC)phenotypic transition in patients with atherosclerosis(AS).Methods A total of 157 AS patients admitted to Renhuai People's Hospital from May 2024 to July 2025 were selected as the study group,and 100 healthy individuals undergoing physical examinations at Renhuai People's Hospital during the same period were enrolled as the control group.General data were collected,the expression level of tRF-His-GTG-037 was detected by qRT-PCR,the markers of VSMC phenotypic transition[α-smooth muscle actin(α-SMA),smooth muscle 22α(SM22α),matrix metalloproteinase-9(MMP-9),and osteopontin(OPN)]were measured using enzyme-linked immuno sorbent assay(ELISA).Results The tRF-His-GTG-037 expression level,MMP-9 and OPN in the study group were higher than those in the control group,α-SMA and SM22α were lower than those in the control group(P<0.05).Pearson correlation analysis results showed that the tRF-His-GTG-037 expression level in AS patients was negatively correlated with α-SMA(r=-0.511,P<0.001)and SM22α(r=-0.568,P<0.001),and positively correlated with MMP-9(r=0.525,P<0.001)and OPN(r=0.548,P<0.001).Conclusion The tRF-His-GTG-037 expression level is elevated in patients with AS.The tRF-His-GTG-037 expression level is negatively correlated with α-SMA and SM22α,and positively correlated with MMP-9 and OPN.关键词
动脉粥样硬化/肌,平滑,血管/tRF-His-GTG-037Key words
Atherosclerosis/Muscle,smooth,vascular/tRF-His-GTG-037分类
医药卫生引用本文复制引用
李新秋,李鲲,吴峰,钟小梅,纪玉强..动脉粥样硬化患者tRF-His-GTG-037表达水平及其与血管平滑肌细胞表型转化标志物的关系研究[J].实用心脑肺血管病杂志,2026,34(7):72-77,6.基金项目
贵州省卫生健康委科学技术基金项目(gzwkj2021-202) （gzwkj2021-202）
