生殖医学杂志2026，Vol.35Issue(5)：587-593,7.DOI:10.3969/j.issn.1004-3845.2026.05.003
长方案促排卵高龄患者抗苗勒管激素水平与成熟卵母细胞数的相关性研究
Correlation between anti-Müllerian hormone level and the number of mature oocytes in elderly patients undergoing ovarian stimulation with GnRH agonist long protocol
摘要
Abstract
Objectives:To investigate the correlation between anti-Müllerian hormone(AMH),antral follicle count(AFC),follicle-stimulating hormone(FSH)/luteinizing hormone(LH)ratio and the number of mature oocytes retrieved in elderly women(≥35 years old)undergoing controlled ovarian hyperstimulation with the gonadotropin-releasing hormone(GnRH)agonist long protocol. Methods:A total of 1 073 female patients aged ≥35 years who underwent assisted reproductive technology with the GnRH agonist long protocol at the Reproductive Medicine Center of Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University from January 2021 to November 2024 were enrolled.The patients were divided into the 35-39 years old group(n=976)and≥40 years old group(n=97).Data on baseline sex hormone levels,AFC,number of mature oocytes and other related outcomes were collected.Multivariate regression analysis was performed to evaluate the associations of AMH,AFC and FSH/LH ratio with the number of mature oocytes. Results:AMH levels and AFC were significantly positively correlated with the number of mature oocytes and blastocyst formation rate(P＜0.05),while the FSH/LH ratio was significantly negatively correlated with the number of mature oocytes(P＜0.05).Multivariate regression analysis showed that AMH(β=0.049,P=0.042)and AFC(β=0.316,P＜0.001)had significant positive effects on the number of mature oocytes.The FSH/LH ratio(β=-0.089,P=0.002)and total dose of gonadotropin(Gn)use(β=-0.165,P＜0.001)had significant negative effects on the number of mature oocytes.Age and body mass index(BMI)had no statistically significant effects on the number of mature oocytes(P＞0.05).There were differences in predictive outcomes between age subgroups.In both the 35-39 years old group and ≥40 years old group,AMH levels and AFC were positive influencing factors for the number of mature oocytes(P＜0.05),whereas the effect of the FSH/LH ratio on the number of mature oocytes was not statistically significant in the ≥40 years old group(P＞0.05). Conclusions:In elderly women undergoing ovarian stimulation with the GnRH agonist long protocol,AMH level,AFC,and FSH/LH ratio were all significantly correlated with the number of mature oocytes retrieved.These indicators for evaluating ovarian reserve can well predict the oocytes retrieved and allow timely adjustment of ovulation induction medications in elderly women.关键词
高龄女性/成熟卵母细胞数/抗苗勒管激素/窦卵泡计数/卵泡刺激素/黄体生成素比值Key words
Elderly woman/Number of mature oocytes/Anti-Müllerian hormone/Antral follicle count/Follicle-stimulating hormone/luteinizing hormone ratio分类
医药卫生引用本文复制引用
丁丽,刘香妍,黄晨阳,王珊珊,孙华..长方案促排卵高龄患者抗苗勒管激素水平与成熟卵母细胞数的相关性研究[J].生殖医学杂志,2026,35(5):587-593,7.基金项目
2024年度南京鼓楼医院新技术发展基金(XJSFZLX202466) （XJSFZLX202466）
