生殖医学杂志2026，Vol.35Issue(5)：645-650,6.DOI:10.3969/j.issn.1004-3845.2026.05.011
基于前瞻性队列研究:维生素D水平对卵巢储备功能正常人群卵泡期长方案促排卵助孕治疗妊娠结局的影响
Based on prospective cohort study:Effect of vitamin D level on pregnancy outcomes of assisted reproductive technology with follicular-phase GnRH agonist long protocol in women with normal ovarian reserve function
摘要
Abstract
Objectives:To investigate the effect of vitamin D level on pregnancy outcomes of in vitro fertilization-embryo transfer(IVF-ET)with follicular-phase gonadotropin-releasing hormone(GnRH)agonist long protocol in women with normal ovarian reserve function. Methods:A total of 380 infertile patients(380 cycles)with normal ovarian reserve function were selected from the Department of Reproductive Medicine of Baoding Maternal & Child Health Hospital who underwent conventional IVF-ET cycles with controlled ovarian stimulation of follicular phase GnRH agonist long protocol from June 2022 to January 2024.Chemiluminescence immunoassay was employed to detect serum 25(OH)D levels before the treatment.According to 25(OH)D levels,they were divided into three groups:vitamin D deficiency group[serum 25(OH)D level＜20.0 ng/ml(50.0 nmol/L),n=135],vitamin D insufficiency group[serum 25(OH)D level 20.0-29.9 ng/ml(50.0-74.9 nmol/L),n=184],and vitamin D sufficiency group[serum 25(OH)D level ≥30.0 ng/ml(75.0 nmol/L),n=61].Ovulation induction related indicators and pregnancy outcomes were compared across the groups. Results:There were no significant differences in basic characteristics such as age,duration of infertility,and body mass index(BMI)among the three groups(P＞0.05).There were no significant differences in total duration of gonadotropin(Gn)use,total dose of Gn use,serum levels of luteinizing hormone(LH),estradiol(E2)and progesterone(P)on human chorionic gonadotropin(HCG)day,number of retrieved oocytes,endometrial thickness on trigger day,and number of transferred embryos among the three groups(P＞0.05).The embryo implantation rate in the vitamin D sufficiency group was significantly higher than those of the other two groups(41.79％vs.33.33％,27.16％,P＜0.001).H owever,there were no significant differences in HCG-positive rate,clinical pregnancy rate,miscarriage rate,live birth rate,and weight and length of newborns among the three groups(P＞0.05). Conclusions:The serum vitamin D levels in infertile women with normal ovarian reserve function have a significant impact on the implantation rate of conventional IVF-ET cycles with follicular-phase GnRH agonist long protocol,while have no significant effect on clinical pregnancy rate and live birth rate in the cycles.关键词
维生素D/卵巢储备功能/卵泡期长方案/体外受精-胚胎移植Key words
Vitamin D/Ovarian reserve function/Follicular-phase GnRH agonist long protocol/In vitro fertilization-embryo transfer分类
医药卫生引用本文复制引用
宋影莹,梁辉,王娜,韩晶,陈英,赵媛媛..基于前瞻性队列研究:维生素D水平对卵巢储备功能正常人群卵泡期长方案促排卵助孕治疗妊娠结局的影响[J].生殖医学杂志,2026,35(5):645-650,6.基金项目
保定市科技计划项目(2241ZF085) （2241ZF085）
