武警医学2026，Vol.37Issue(5)：398-405,8.DOI:10.3969/j.issn.1004-3594.2026.05.006
甲状腺功能障碍与泌尿系结石的因果关系:一项两样本孟德尔随机化研究
Study of the causal relationship between thyroid dysfunction and urolithiasis through two-sample Mendelian randomization
摘要
Abstract
Objective To explore the causal relationship between thyroid disorders and urolithiasis through Mendelian ran-domization(MR).Methods Data on hyperthyroidism,hypothyroidism,thyroid cancer,thyroid-stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine/free thyroxine(FT3/FT4),and urolithiasis were collected from large-scale genome-wide associ-ation studies(GWAS).A two-sample MR analysis was conducted.The study included data from individuals of European ancestry.Causal associations between thyroid disorders and urolithiasis were assessed using inverse variance weighting(IVW),MR-Egger re-gression,weighted median,and weighted mode methods.Cochran's test was used to evaluate heterogeneity,and the MR-Egger inter-cept test was applied to assess horizontal pleiotropy.The MR-PRESSO method was employed to detect and correct potential outlier in-strumental variables.Results The IVW method showed a negative causal relationship between hypothyroidism and urolithiasis,indica-ting that hypothyroidism could reduce the risk of urolithiasis(OR=0.939,95%CI=0.8823-0.9993,P=0.047).No causal associations were observed between hyperthyroidism,thyroid cancer,serum TSH,FT4,FT3/FT4 and the risk of urolithiasis.No significant heteroge-neity or horizontal pleiotropy was detected.Conclusions There is a potential causal relationship between hypothyroidism and urolithiasis.关键词
泌尿系结石/甲状腺功能减退/甲状腺功能亢进/孟德尔随机化/因果关系Key words
urolithiasis/hypothyroidism/hyperthyroidism/Mendelian randomization/causal relationship分类
医药卫生引用本文复制引用
赵本隆,赵伦杰,魏洋洋,潘金生,石秀全,杨柳生,熊朝晖..甲状腺功能障碍与泌尿系结石的因果关系:一项两样本孟德尔随机化研究[J].武警医学,2026,37(5):398-405,8.基金项目
安徽中医药大学2024年度临床科研项目(2024LC060) （2024LC060）
