武警医学2026，Vol.37Issue(5)：406-411,6.DOI:10.3969/j.issn.1004-3594.2026.05.007
同型半胱氨酸与子痫前期的因果关联:孟德尔随机化研究
Study of the causal association between homocysteine and preeclampsia through Mende-lian randomization
摘要
Abstract
Objective To evaluate the causal association between homocysteine(Hcy)and preeclampsia through two-sample Mendelian randomization(MR).Methods Based on the data from genome-wide association studies(GWAS),a forward analysis was conducted with Hcy as the exposure and preeclampsia as the outcome.Genetic variants significantly associated with Hcy(SNPs)were selected as instrumental variables,and the inverse variance weighted method(IVW)was used as the main analysis method,supple-mented by MR-Egger regression for sensitivity analysis.Heterogeneity and horizontal pleiotropy were assessed using Cochran's Q test and the MR-Egger intercept tests respectively,and the leave-one-out analysis was performed to examine the influence of individual SNPs.In the reverse-direction analysis,preeclampsia was treated as the exposure and Hcy as the outcome.Results Genetically pre-dicted higher Hcy levels were causally associated with an increased risk of preeclampsia.Each 1-unit increase in Hcy was associated with significantly higher risk of preeclampsia(OR=3.92,P=2.97×10-6),with no significant heterogeneity or horizontal pleiotropy,supporting the robustness of the findings.The reverse-direction analysis showed a negative association between preeclampsia suscepti-bility and Hcy levels.For each 1 standard deviation increase in genetic risk of preeclampsia,Hcy decreased by approximately 0.52 u-nits(β=-0.519,SE=0.103,P=4.75×10-7).Conclusions Based on genetic data,the overall evidence supports a positive causal association between homocysteine and preeclampsia,suggesting a potential etiological role for Hcy.关键词
同型半胱氨酸/子痫前期/孟德尔随机化/因果关联/全基因组关联研究Key words
homocysteine/preeclampsia/Mendelian randomization/causal association/genome-wide association study分类
医药卫生引用本文复制引用
于博,檀亚航,黄诗韵..同型半胱氨酸与子痫前期的因果关联:孟德尔随机化研究[J].武警医学,2026,37(5):406-411,6.基金项目
国家自然青年科学基金(编号:62106160) （编号:62106160）
