现代医药卫生2026，Vol.42Issue(5)：1122-1127,6.DOI:10.3969/j.issn.1009-5519.2026.05.034
结核病亚单位疫苗的免疫机制和免疫保护性研究进展
Research progress on the immune mechanism and immunoprotection of tuberculosis subunit vaccines
摘要
Abstract
At present,Tuberculosis remains one of the most dangerous epidemic infectious diseases in the world.Its increasing incidence,particularly in recent years,poses a great threat to public health and human well-being.Vaccination is one of the most direct and effective means for the prevention and control of tubercu-losis.However,the only approved and widely used protective vaccine in clinical practice is Bacillus Calmette-Guérin(BCG),which has poor protective efficacy in adults.In contrast,subunit vaccines offer higher immuno-protection,safety,stability,and ease of standardization,presenting promising prospects for development.This article reviews the immune mechanism,effective components,research progress,and challenges of tuberculosis subunit vaccines.关键词
结核病/亚单位疫苗/卡介苗/免疫机制/综述Key words
Tuberculosis/Subunit vaccine/Bacillus Calmette-Guérin/Immune mechanism/Re-view分类
医药卫生引用本文复制引用
高志成,王晓春,徐乾..结核病亚单位疫苗的免疫机制和免疫保护性研究进展[J].现代医药卫生,2026,42(5):1122-1127,6.基金项目
大学生创新创业训练计划项目(S202310361257). （S202310361257）
