协和医学杂志2026，Vol.17Issue(3)：607-616,10.DOI:10.12290/xhyxzz.2025-1072
磨玻璃结节的进展与肺癌演化:分子与影像学研究
Progress of Ground-Glass Nodules and Lung Cancer Evolution:Molecular and Imaging Studies
摘要
Abstract
Ground-glass nodules(GGNs)are common imaging manifestation in the early screening of lung adenocarcinoma.With the widespread use of low-dose computed tomography(LDCT)in lung cancer screening,the detection rate of GGNs has significantly increased.According to the presence or absence of a solid component,GGNs are mainly classified into pure ground-glass nodules(pGGNs)and mixed ground-glass nodules(mGGNs),which differ in their natural course and biological behavior.In general,pGGNs tend to pro-gress more slowly,whereas mGGNs are more likely to develop invasive features.The vast majority of pGGNs re-main stable for years,but some pGGNs and mGGNs may show an increase in size or in the solid component.The"indolence"observed on the surface of GGNs hides complex genomic,metabolic,and immune changes,which are difficult to capture with traditional image-based data.In recent years,multi-omics analysis,radiomics,and artificial intelligence models have provided new tools for identifying high-risk GGNs.However,there is still controversy over the clinical generalizability,interpretability,and standardization of these models.Furthermore,there is no consensus on whether surgical resection is required.This article reviews the molecular mechanisms,metabolic,and immune microenvironment changes involved in the progression of GGNs,discusses the advantages and limitations of imaging prediction models,and combines domestic and international guidelines and survival studies to explore the controversial points in follow-up and surgical strategies,aiming to provide references for the personalized management of GGNs.关键词
磨玻璃结节/肺腺癌/免疫微环境/影像组学/随访策略Key words
ground-glass nodules/lung adenocarcinoma/immune microenvironment/radiomics/follow-up strategies分类
医药卫生引用本文复制引用
慕家兴,李浩,陈克终..磨玻璃结节的进展与肺癌演化:分子与影像学研究[J].协和医学杂志,2026,17(3):607-616,10.基金项目
国家自然科学基金(82450111,82525052,82388102,82373416) （82450111,82525052,82388102,82373416）
四大慢病重大专项(2023ZD0501900) （2023ZD0501900）
研究型病房卓越临床研究计划(BRWEP2024W034080204) （BRWEP2024W034080204）
北京市自然科学基金(L222021,QY24068) （L222021,QY24068）
北京大学人民医院科研发展基金(RZG2024-02) National Natural Science Foundation of China(82450111,82525052,82388102,82373416) （RZG2024-02）
Major Program for Four Major Chronic Diseases(2023ZD0501900) （2023ZD0501900）
Excellence Clinical Research Program of Research Wards(BRWEP2024W034080204) （BRWEP2024W034080204）
Beijing Natural Science Foundation(L222021,QY24068) （L222021,QY24068）
Research and Development Fund of Peking University People's Hospital(RZG2024-02) （RZG2024-02）
