协和医学杂志2026，Vol.17Issue(3)：726-734,9.DOI:10.12290/xhyxzz.2025-0418
阿尔茨海默病与淋巴显微外科:迷雾与未解之谜
Alzheimer's Disease and Lymphatic Microsurgery:Navigating the Unknown
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by hallmark patho-logical features,including β-amyloid deposition,neurofibrillary tangles formed by hyperphosphorylated tau pro-tein,and chronic neuroinflammation.Recent studies have revealed that the glymphatic-meningeal-cervical lym-phatic system plays a pivotal role in intracranial metabolic waste clearance,and its dysfunction may impair the clearance efficiency of β-amyloid and tau proteins.Based on this mechanism,domestic scholars have innova-tively proposed lympho-microsurgical reconstruction of the brain-cervical lymphatic drainage pathway,aiming to ameliorate AD pathological progression and cognitive function by enhancing intracranial waste clearance.Through a comprehensive literature review,this article focuses on the theoretical rationale for lympho-microsur-gical intervention in AD.While critically evaluating existing surgical approaches and efficacy assessment systems,it further examines the fundamental scientific challenges and clinical translation barriers in directly applying this technique to AD treatment,with the goal of providing theoretical insights and methodological guid-ance for future research.关键词
阿尔茨海默病/淋巴显微外科/胶质淋巴系统/脑膜淋巴管/颈深淋巴结Key words
Alzheimer's disease/lympho-microsurgery/glymphatic system/meningeal lymphatic vessels/deep cervical lymph nodes分类
医药卫生引用本文复制引用
张梦原,谭兆琦,郭路齐,刘浩,黄久佐,俞楠泽,龙笑..阿尔茨海默病与淋巴显微外科:迷雾与未解之谜[J].协和医学杂志,2026,17(3):726-734,9.基金项目
中央高水平医院临床科研专项(2022-PUMCH-C-025) National High Level Hospital Clinical Research Funding(2022-PUMCH-C-025) （2022-PUMCH-C-025）
