畜牧兽医学报2026，Vol.57Issue(5)：2445-2459,15.DOI:10.11843/j.issn.0366-6964.2026.05.006
肠道微生物组与宿主DNA甲基化互作对动物生长发育及健康的影响研究进展
Research Progress on the Interaction between Gut Microbiome and Host DNA Methylation and Its Impact on Animal Growth,Development,and Health
摘要
Abstract
Animal gut microbiome is a complex ecosystem composed of bacteria,fungi,protozoa,bacteriophages,and other microorganisms.Through synergistic interactions,it maintains intestinal microecological balance and deeply participates in host physiological regulation,immune responses,and metabolic functions.Dysbiosis of gut microbiota not only restricts host growth and development,causes immune disorders,and metabolic diseases but also interacts with host genomes via microbial metabolites to affect epigenetic modifications(e.g.,DNA methylation),thereby exerting profound impacts on host health.As a key epigenetic mechanism,DNA methylation shapes host physiological phenotypes by regulating gene expression and maintaining genomic stability.However,the collaborative mechanisms between DNA methylation and gut microbiota remain unclear.This paper reviews the interaction patterns between gut microbiome and DNA methylation,focusing on the regulatory pathways of microbial metabolites on host methylation modifications and the potential mechanisms by which they jointly influence animal health,growth and development,and production performance.Aiming to provide a theoretical basis and research perspective for optimizing animal production performance and regulating host health,and to promote the application of research on gut microbiota-epigenetic interactions in the livestock sector.关键词
肠道微生物群/DNA甲基化/生长发育/肠道健康Key words
gut microbiota/DNA methylation/growth and development/gut health分类
农业科技引用本文复制引用
何亚鹏,陈倩玲,沙玉柱,陈小伟,黄薇,高旭,陈国顺,刘秀..肠道微生物组与宿主DNA甲基化互作对动物生长发育及健康的影响研究进展[J].畜牧兽医学报,2026,57(5):2445-2459,15.基金项目
国家自然科学基金项目(32260820) （32260820）
甘肃省高校产业支撑计划项目(2025CYZC-043) （2025CYZC-043）
甘肃农业大学科技创新基金项目(GAU-QDFC-2022-06) （GAU-QDFC-2022-06）
