畜牧与兽医2026，Vol.58Issue(6)：114-123,10.
活筋壮骨散对大鼠骨关节炎的治疗作用研究
Study on the therapeutic effect of Chinese herbal compound HJZGS on osteoarthritis in rats
摘要
Abstract
Osteoarthritis(OA)is a common chronic disease,characterized mainly by cartilage degeneration,joint pain,inflammation,and gradual loss of joint function.Huojin Zhuanggu San(HJZGS),a traditional Chinese medicine compound,composed of six herbal ingredi-ents,was evaluated in this study for its therapeutic effects and potential mechanisms of action on OA using an OA rat model.In vivo,the OA rat model was established by intra-articular injection of sodium monoiodoacetate.After 21 days of oral administration of HJZGS,the thera-peutic effects were assessed by histological observation and measurement of serum cytokine levels.In vitro,inflammation was induced in RAW 264.7 cells using LPS.The polarization of macrophages,mitochondrial membrane potential,reactive oxygen species(ROS)produc-tion,cell cycle and apoptosis were detected after HJZGS intervention to evaluate the anti-inflammatory ability of HJZGS.The in vivo study demonstrated that HJZGS significantly alleviated joint cartilage damage in OA rats and reduced the levels of pro-inflammatory cytokines such as IL-6 and TNF-α in serum.The in vitro study showed that HJZGS modulated macrophages polarization,promoting the shift of macrophages from the M1 to the M2 phenotype,thereby exerting anti-inflammatory effects.Additionally,HJZGS reduced the production of ROS,en-hanced cellular antioxidant capacity,and rescued mitochondrial membrane potential,thereby minimizing cell damage.HJZGS effectively alle-viated sodium monoiodoacetate-induced OA in rats by modulating macrophages polarization and inhibiting inflammation and oxidative stress.This finding provided experimental evidence for application of HJZGS in veterinary treatment of canine OA and laid a theoretical foundation for development of functional pet food additives.关键词
中药复方/骨关节炎/巨噬细胞极化/氧化应激Key words
Chinese herbal compound/osteoarthritis/macrophage polarization/oxidative stress分类
农业科技引用本文复制引用
张智敏,马昌浩,左岩峰,丁睿,仇亚伟,刘振广,宋祖晨,葛新成,焦丽娜,余蕊宏,马岩,王政,张露露..活筋壮骨散对大鼠骨关节炎的治疗作用研究[J].畜牧与兽医,2026,58(6):114-123,10.基金项目
宠物功效食品开发项目(HMQY24081) （HMQY24081）
