畜牧与兽医2026，Vol.58Issue(6)：146-153,8.
副鸡禽杆菌疫苗研究进展
Progress in research on vaccines against Avibacterium paragallinarum
摘要
Abstract
Avibacterium paragallinarum(Av.paragallinarum),the causative agent of infectious coryza in chickens,induces severe acute upper respiratory inflammation.This disease significantly compromises flock health,resulting in growth retardation,reduced egg production,and high mortality,leading to substantial economic losses in the poultry industry.In recent years,the prevalence of this disease in China has shown no significant decline,with the prevalence of serovar B continuing to rise,posing significant challenges to control efforts.Vaccination remains the cornerstone of prevention and control of this pathogen.However,the protective efficacy of commercial inactivated vaccines is of-ten limited due to antigenic mismatch between circulating field strains and vaccine strains.Therefore,there is an urgent need for expanding vaccine strain libraries or developing novel vaccines,such as genetically engineered vaccines,to address the challenge of antigenic heteroge-neity.This review comprehensively summarizes current research on Av.paragallinarum vaccines,including inactivated vaccines,attenuated live vaccines,subunit vaccines,and other vaccine types,aiming to provide valuable references for future vaccine development.关键词
副鸡禽杆菌/鸡传染性鼻炎/疫苗/防控Key words
Avibacterium paragallinarum/infectious coryza/vaccine/control分类
农业科技引用本文复制引用
胡静,蔡联燊,荣俊,梅东杰,黄绮雯,叶十一,李国攀,熊涛..副鸡禽杆菌疫苗研究进展[J].畜牧与兽医,2026,58(6):146-153,8.基金项目
兽医生物技术国家重点实验室开放课题资助青年基金项目(SKLVBF202002) （SKLVBF202002）
