摘要
Abstract
Objective:To observe the efficacy of Ziyin Yangxue Hejie Decoction in treating dry eye syndrome of yin deficiency and damp-heat type,and to explore its effects on fibroblast growth factor receptor 2(FGFR2)in tears and tear film break-up time(BUT).Methods:A total of 126 patients(252 eyes)with dry eye syndrome admitted to the Department of Ophthalmology of Pingdingshan The Second People's Hospital from October 2023 to August 2025 were selected and randomly divided into a control group and an observation group using a random number table method,with 63 cases(126 eyes)in each group.The control group received routine eye drop treatment,while the observation group received additional Ziyin Yangxue Hejie Decoction based on the control group's treatment.Both groups were treated for one consecutive month.Clinical efficacy was evaluated,and traditional Chinese medicine syndrome scores,tear-related indicators,and FGFR2 levels were compared between the two groups.The incidence of adverse reactions was also recorded.Results:The total effective rate was 95.24%(60/63)in the observation group,higher than that of 82.54%(52/63)in the control group(P＜0.05).After treatment,traditional Chinese medicine syndrome scores decreased in both groups compared to before treatment(P＜0.05),and the observation group had lower scores than the control group(P＜0.05).After treatment,tear film BUT,Schirmer Ⅰ test(S Ⅰ t)values,and FGFR2 levels increased in both groups compared to before treatment,while corneal fluorescein staining(FL)scores decreased(P＜0.05).The observation group showed higher BUT,S Ⅰ t values,and FGFR2 levels,and lower FL scores than the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Ziyin Yangxue Hejie Decoction demonstrates significant clinical efficacy in treating dry eye syndrome of yin deficiency and damp-heat type.It improves clinical symptoms and tear-related indicators,increases FGFR2 levels,and exhibits a high safety profile.关键词
干眼症/阴虚湿热型/滋阴养血和解汤/成纤维细胞生长因子受体/泪膜破裂时间Key words
Dry eye syndrome/Yin deficiency and damp-heat type/Ziyin Yangxue Hejie Decoction/Fibroblast growth factor receptor 2/Tear film break-up time分类
医药卫生
