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Breaking the boundaries of affinity selection-mass spectrometry:From ligand screening to target-ligand interaction insights

Bruno Sérgio do Amaral Carmen Lucia Cardoso Quezia Bezerra Cass Marcela Cristina De Moraes

药物分析学报（英文）2026，Vol.16Issue(2)：347-358,12.

药物分析学报（英文）2026，Vol.16Issue(2)：347-358,12.DOI:10.1016/j.jpha.2025.101379

Breaking the boundaries of affinity selection-mass spectrometry:From ligand screening to target-ligand interaction insights

Bruno Sérgio do Amaral ¹Carmen Lucia Cardoso ²Quezia Bezerra Cass ³Marcela Cristina De Moraes⁴

作者信息

1. Federal Institute of Education,Science and Technology of São Paulo,São Paulo,05110-000,Brazil
2. Department of Chemistry,Faculty of Philosophy,Sciences and Letters of Ribeirão Preto,University of São Paulo,Ribeirão Preto,14040-900,Brazil
3. Department of Chemistry,Federal University of São Carlos,São Carlos,13565-905,Brazil
4. Department of Organic Chemistry,Fluminense Federal University,Niterói,24020-007,Brazil
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摘要

关键词

Affinity selection mass spectrometry/Competition assays/Drug discovery/Fragment screening/KD determination/Ligand-target interactions/Molecular glues

Key words

Affinity selection mass spectrometry/Competition assays/Drug discovery/Fragment screening/KD determination/Ligand-target interactions/Molecular glues

引用本文复制引用

Bruno Sérgio do Amaral,Carmen Lucia Cardoso,Quezia Bezerra Cass,Marcela Cristina De Moraes..Breaking the boundaries of affinity selection-mass spectrometry:From ligand screening to target-ligand interaction insights[J].药物分析学报（英文）,2026,16(2):347-358,12.

基金项目

The authors acknowledge Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro(FAPERJ),Brazil(Grant Nos.:E-26/210.017/2024,E-200.172/2023,E-26/200.165/2024,E-26/200.164/2024,and E-26/210.547/2025),the Coordina-tion for the Improvement of Higher Education Personnel(CAPES),Brazil(Finance Code 001),and National Council for Scientific and Technological Development(CNPq),Brazil(Grant Nos.:307108/2021-0 and 302464/2022-0)for their support.All figures,including Graphical abstract,were created with BioRender.com. （FAPERJ）

药物分析学报（英文）

ISSN：2095-1779

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