首页|期刊导航|药物分析学报（英文）|CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalability

CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalability

Yao He Xiao Tu Yuxin Xue Yuxuan Chen Bengui Ye Xiaojie Li Dapeng Li Zhihui Zhong Qixing Zhong

药物分析学报（英文）2026，Vol.16Issue(2)：359-376,18.

药物分析学报（英文）2026，Vol.16Issue(2)：359-376,18.DOI:10.1016/j.jpha.2025.101357

CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalability

Yao He ¹Xiao Tu ²Yuxin Xue ¹Yuxuan Chen ³Bengui Ye ⁴Xiaojie Li ¹Dapeng Li ³Zhihui Zhong ¹Qixing Zhong⁵

作者信息

1. Laboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,China
2. Laboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,China||Medical Innovation Center,Sichuan University of Science & Engineering,Zigong,Sichuan,643002,China
3. Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,China
4. Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,610041,China||Medical College of Tibet University,Lasa,850002,China
5. Laboratory of Neurological Disease Modeling and Translational Research,West China Hospital,Sichuan University,Chengdu,610041,China||Tianfu Jincheng Laboratory,City of Future Medicine,Chengdu,641400,China
折叠

摘要

关键词

CRISPR-Cas/Gene editing/Targets identification/Drug discovery

Key words

CRISPR-Cas/Gene editing/Targets identification/Drug discovery

引用本文复制引用

Yao He,Xiao Tu,Yuxin Xue,Yuxuan Chen,Bengui Ye,Xiaojie Li,Dapeng Li,Zhihui Zhong,Qixing Zhong..CRISPR screening redefines therapeutic target identification and drug discovery with precision and scalability[J].药物分析学报（英文）,2026,16(2):359-376,18.

基金项目

This project was supported by National Natural Science Foun-dation of China(Grant No.:82071349),Sichuan Science and Technology Program,China(Grant No.:2025ZNSFSC0703),Young Scientists Fund of the National Natural Science Foundation of China(Grant No.:82204513),Natural Science Foundation of Sichuan Province,China(Grant No.:2023NSFSC1673),Innovation Guidance Foundation of the Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,China(Grant No.:SCU2023D005),and Scientific Research Staring Foundation of Sichuan University,China(Grant No.:YJ202165).The authors would like to thank Sichuan Junhui Biotechnology Co.,Ltd.and Singapore HumanSim Pte.Ltd.for helping this study. （Grant No.:82071349）

药物分析学报（英文）

ISSN：2095-1779

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