Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanism
Guang-Hao Zhu Ya-Ni Zhang Yuan Xiong Xu-Dong Hou Qing-Guang Zhang Zhao-Qin Zhang Xiao-Yu Zhuang Wei-Dong Zhang Guang-Bo Ge
Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanism
Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanism
摘要
关键词
SARS-CoV-2 Mpro/Rhodiola crenulata root/Covalent inhibitor/Synergistic effect/Allosteric inhibition/Cooperative modificationKey words
SARS-CoV-2 Mpro/Rhodiola crenulata root/Covalent inhibitor/Synergistic effect/Allosteric inhibition/Cooperative modification引用本文复制引用
Guang-Hao Zhu,Ya-Ni Zhang,Yuan Xiong,Xu-Dong Hou,Qing-Guang Zhang,Zhao-Qin Zhang,Xiao-Yu Zhuang,Wei-Dong Zhang,Guang-Bo Ge..Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanism[J].药物分析学报（英文）,2026,16(2):473-487,15.基金项目
This work was financially supported by the National Natural Science Foundation of China(Grant Nos.:82141203,82273897,U23A20516,82204606,and 82104281),the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine,China(Grant No.:2023YZZ02),Shanghai Municipal Health Commission's TCM Research Project,China(Grant No.:2022CX005),Shanghai Science and Technology Innovation Action Plans,China(Grant No.:21S21900600),the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine,China(Grant No.:2023YZZ02),Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine,China(Grant No.:ZYYCXTD-D-202004),Shanghai Talent Development Fund,China(Grant No.:2019093),Shanghai Sailing Program,China(Program No.:22YF1441500),and Three-year Action Plan for Shanghai TCM Development and Inheritance Program,China(Grant No.:ZY(2021-2023)-0401). （Grant Nos.:82141203,82273897,U23A20516,82204606,and 82104281）
