We are grateful for financial support from the Collaborative Science and Technology Project jointly funded by the Science and Technology Department of the National Administration of Tradi-tional Chinese Medicine and the Zhejiang Provincial Administra-tion of Traditional Chinese Medicine(Grant No.:GZY-ZJ-KJ-24038),the Basic scientific research Project of Wenzhou(Project No.:H20210010),the National Natural Science Foundation of China(Grant No.:82241001)and the Natural Science Foundation of Zhejiang province(Grant No.:LZ23H010001). （Grant No.:GZY-ZJ-KJ-24038）