医学信息2026，Vol.39Issue(10)：118-121,126,5.DOI:10.3969/j.issn.1006-1959.2026.10.020
腺病毒感染患儿细胞因子及淋巴细胞亚群与病情预后的相关性研究
Study on the Correlation Between Cytokines and Lymphocyte Subsets and Prognosis in Children with Adenovirus Infection
摘要
Abstract
Objective To investigate the correlation between the levels of cytokines and lymphocyte subsets in children with adenovirus infection and the prognosis of the disease,and to provide a theoretical basis for clinical diagnosis,treatment and prognosis evaluation.Methods From February 2023 to January 2025,33 children with adenovirus infection and 33 children without adenovirus infection admitted to Anyuan County People's Hospital during the same period were selected as the research objects.They were divided into infection group and non-infection group.The levels of serum interleukin-2(IL-2),IL-4,IL-6,IL-10,tumor necrosis factor(TNF)and interferon-γ(IFN-γ)were detected by flow cytometry.The ratio of CD3+,CD4+,CD8+and CD4+/CD8+in peripheral blood was detected by flow cytometry.The correlation between the above indexes and the prognosis of the disease was analyzed.Results The levels of IL-2,IL-4,IL-6,IL-10 and TNF in the infected group were higher than those in the non-infection group,while the levels of IFN-γ were lower than those in the non-infection group(P＜0.05).The levels of lymphocyte subsets in the infected group were lower than those in the non-infection group(P＜0.05).Correlation analysis showed that the levels of IL-2,IL-4,IL-6,IL-10 and TNF were positively correlated with the prognosis of children with adenovirus infection(r=0.653,0.584,0.727,0.682,0.754,P＜0.05).The levels of IFN-γ,CD3+,CD4+,CD8+and CD4+/CD8+were negatively correlated with the prognosis of children with adenovirus infection(r=-0.626,-0.554,-0.608,-0.506,-0.703,P＜0.05).Conclusion The levels of cytokines and lymphocyte subsets in children with adenovirus infection are closely related to the prognosis of the disease,which can be used as potential biomarkers and therapeutic targets to provide new ideas for improving the prognosis of children.关键词
腺病毒感染/细胞因子/淋巴细胞亚群/预后Key words
Adenovirus infection/Cytokines/Lymphocyte subsets/Prognosis分类
医药卫生引用本文复制引用
赖龙飞,黄祥美,钟石古..腺病毒感染患儿细胞因子及淋巴细胞亚群与病情预后的相关性研究[J].医学信息,2026,39(10):118-121,126,5.基金项目
赣州市指导性科技计划项目(编号:GZ2024ZSF649) （编号:GZ2024ZSF649）
