应用化学2026，Vol.43Issue(5)：677-685,9.DOI:10.19894/j.issn.1000-0518.250341
基于环糊精结构修饰的载体给药系统研究进展
Advances in Carrier Drug Delivery Systems Based on Cyclodextrins Structural Modification
摘要
Abstract
Poor solubility and permeability are among the key factors affectingthe drugability of pharmaceuticals.In recent years,drug delivery strategies based on cyclodextrins(CDs)and their derivatives have garnered significant attention due to their remarkable advantages in improving drug properties.CDs are cyclic oligosaccharides with an internal hydrophobic external hydrophilic structure.Its derivatives,obtained through chemical modification,supramolecular chemistry modifications,or functionalization,can not only effectively address issues related to drug solubility and permeability but also enhance the targeting or stimulus responsiveness of drug delivery,enabling intelligent and precise drug delivery.This article elucidates the structural modification strategies of cyclodextrins,systematically summarizes the applications of these modifications in drug delivery systems,and discusses current challenges,aiming to provide valuable insights for promoting in-depth research and translational applications of CD-based carrier delivery systems.关键词
环糊精/结构修饰/药物递送/新型给药系统/靶向性Key words
Cyclodextrins/Structure modification/Drug delivery/Advanced drug delivery systems/Targeting specificity分类
化学化工引用本文复制引用
黄诗雨,胡煜萍,陈丽华,陈振华..基于环糊精结构修饰的载体给药系统研究进展[J].应用化学,2026,43(5):677-685,9.基金项目
全国重点实验室自主部署重点研发计划项目(No.20243BCC31008)资助 Supported by the Key Research and Development Program of National Key Laboratories(No.20243BCC31008) （No.20243BCC31008）
