中风与神经疾病杂志2026，Vol.43Issue(5)：387-391,5.DOI:10.19845/j.cnki.zfysjjbzz.2026.0066
药物性震颤的表面肌电特点
Surface electromyography characteristics of drug-induced tremor
摘要
Abstract
Objective To investigate the surface electromyography(sEMG)characteristics of drug-induced tremor,and to identify electrophysiological biomarkers for differentiating it from tremor caused by Parkinson disease(PD).Methods A total of 50 patients with drug-induced tremor and 71 patients with PD were enrolled.The sEMG sig-nals from bilateral radial wrist extensors and flexors,along with accelerometer signals,were recorded under resting and pos-tural conditions.Tremor frequency,amplitude,contraction pattern,and harmonic resonance were analyzed.Results The pa-tients in the drug-induced tremor group exhibited symmetrical bilateral tremor,with a higher proportion of patients with mandibular tremor compared with the PD group(70%vs 42.25%,χ2=9.09,P=0.003).Compared with the PD group,the drug-induced tremor group had a significantly higher tremor frequency under both resting and postural conditions[(6.43±0.41)Hz/(6.57±0.33)Hz vs(4.68±0.27)Hz,F=620.64,P<0.001],while there was no significant difference in tremor amplitude.Compared with the PD group,the drug-induced tremor group had a significantly lower proportion of patients with alternating contraction pattern under both resting(χ2=23.20,P<0.001)and postural(χ2=27.52,P<0.001)condi-tions,as well as a significantly lower proportion of patients with harmonic resonance under both resting(χ2=26.64,P<0.001)and postural(χ2=22.32,P<0.001)conditions.Conclusion Drug-induced tremor has the following electrophysi-ological features:bilateral symmetry,a higher prevalence rate of mandibular tremor,a higher tremor frequency,and a lower proportion of patients with alternating contraction pattern and harmonic resonance,which can provide objective evidence for differentiating drug-induced tremor from PD in clinical practice.关键词
药物性震颤/帕金森病/表面肌电/震颤Key words
Drug-induced tremor/Parkinson disease/Surface electromyography/Tremor分类
医药卫生引用本文复制引用
冯焕焕,刘婧玥,李艳敏,许二赫..药物性震颤的表面肌电特点[J].中风与神经疾病杂志,2026,43(5):387-391,5.基金项目
国家重点研发计划(2021YFC2501200) （2021YFC2501200）
首都医科大学校自然-科研培育基金(PYZ24051) （PYZ24051）
首都医科大学宣武医院院级课题-临床研究项目(LCYJ202413) （LCYJ202413）
