中风与神经疾病杂志2026，Vol.43Issue(5)：407-411,5.DOI:10.19845/j.cnki.zfysjjbzz.2026.0070
帕金森病自主神经障碍的中枢机制与精准神经调控治疗研究进展
Central mechanisms of autonomic dysfunction in Parkinson disease and research advances in precise neuromodulation therapy
摘要
Abstract
The pathological mechanism of neurogenic orthostatic hypotension(nOH)in Parkinson disease(PD)is shifting from peripheral sympathetic denervation to central network dysfunction.This article explores the core role of locus coeruleus(LC)degeneration and abnormalities in the central autonomic network(CAN)and the somato-cognitive action network(SCAN)in the pathogenesis of nOH.A current research challenge lies in determining whether network hypercon-nectivity is physiological compensation or a pathological marker,with a lack of longitudinal multimodal imaging data.Based on the novel understanding of CAN/SCAN impairment,the treatment of PD with nOH is transitioning towards pre-cise neuromodulation paradigms,including SCAN-targeted cortical stimulation,epidural spinal cord stimulation,and closed-loop neuromodulation,which provides new perspectives for individualized management in clinical practice.关键词
帕金森病/神经原性直立性低血压/自主神经网络/脑干蓝斑/神经调控Key words
Parkinson disease/Neurogenic orthostatic hypotension/Autonomic network/Locus coeru-leus/Neuromodulation分类
医药卫生引用本文复制引用
谢紫馨,杜继臣,万志荣,马梓滨,赵静,王馨悦,马少辰,石翀,王培福,李继来,杨静..帕金森病自主神经障碍的中枢机制与精准神经调控治疗研究进展[J].中风与神经疾病杂志,2026,43(5):407-411,5.基金项目
航天中心医院科研基金项目(YN202411) （YN202411）
