中风与神经疾病杂志2026，Vol.43Issue(5)：436-442,7.DOI:10.19845/j.cnki.zfysjjbzz.2026.0076
血清IL-6与hs-CRP对老年急性缺血性脑卒中合并重症肺炎患者预后的影响
Impact of serum interleukin-6 and high-sensitivity C-reactive protein on the prognosis of elderly patients with acute ischemic stroke and severe pneumonia
摘要
Abstract
Objective To investigate the impact of serum interleukin-6(IL-6)and high-sensitivity C-reactive pro-tein(hs-CRP)on the prognosis of elderly patients with acute ischemic stroke(AIS)and severe pneumonia(SP).Methods A total of 172 elderly patients with AIS and SP who were admitted to our hospital from January 2022 to March 2025 were enrolled,and according to their 90-day follow-up results,they were divided into death group and survival group.The two groups were compared in terms of the serum levels of IL-6 and hs-CRP and general information;a multi-variate logistic regression analysis was used to identify independent influencing factors for the prognosis of elderly patients with AIS and SP;the receiver operating characteristic(ROC)curve analysis was used to evaluate the value of IL-6 and hs-CRP used alone or in combination,as well as age and National Institutes of Health Stroke Scale(NIHSS)score,in predict-ing the prognosis of patients with AIS and SP.Results Among the 172 patients after follow-up for 90 days,10 were lost to follow-up,and the remaining 162 patients had a 90-day mortality rate of 38.89%.The death group had significantly higher serum levels of IL-6 and hs-CRP than the survival group(P<0.05).The multivariate logistic regression analysis showed that an older age(OR=2.105,95%CI 1.142‒3.880,P<0.05),an increase in NIHSS score(OR=3.259,95%CI 1.469-7.229,P<0.05),the presence of dysphagia(OR=2.317,95%CI 1.344‒3.995,P<0.05),and an increase in IL-6(OR=2.862,95%CI 1.435‒5.707,P<0.05),and an increase in hs-CRP(OR=3.834,95%CI 1.656‒8.874,P<0.05)were risk factors for poor prognosis in elderly patients with AIS and SP.The ROC curve analysis showed that IL-6 and hs-CRP had a larger area under the ROC curve(AUC)than age and NIHSS score in predicting poor prognosis in elderly pa-tients with AIS and SP,and pairwise comparisons showed that combined measurement of IL-6 and hs-CRP had a larger AUC than IL-6 or hs-CRP alone in predicting poor prognosis in elderly patients with AIS and SP(Z=2.663,P=0.0077;Z=2.197,P=0.028).Conclusion Age,NIHSS score,comorbid-ity with dysphagia,IL-6,and hs-CRP are independent risk factors for the prognosis of elderly patients with AIS and SP,and the combination of IL-6 and hs-CRP has a relatively high value in predicting poor prognosis in elderly patients with AIS and SP.关键词
白细胞介素-6/超敏C反应蛋白/卒中/肺炎/预后Key words
Interleukin-6/High-sensitivity C-reactive protein/Stroke/Pneumonia/Prognosis分类
医药卫生引用本文复制引用
余鸽鸽,宋丁,阮春云,李文波,赵星鹏..血清IL-6与hs-CRP对老年急性缺血性脑卒中合并重症肺炎患者预后的影响[J].中风与神经疾病杂志,2026,43(5):436-442,7.基金项目
2021年度河南省医学科技攻关计划联合共建项目(LHGJ20210843) （LHGJ20210843）
