中国临床药理学杂志2026，Vol.42Issue(8)：1064-1069,6.DOI:10.13699/j.cnki.1001-6821.2026.08.003
烯丙雌醇联合盐酸利托君治疗妊娠期糖尿病先兆早产患者的临床研究
Clinical trial of allylestrenol combined with ritodrine hydrochloride in the treatment of pregnant women with gestational diabetes mellitus and threatened premature labor
摘要
Abstract
Objective To observe the clinical efficacy and safety of allylestrenol tablet combined with ritodrine hydrochloride tablet in the treatment of patients with gestational diabetes mellitus and threatened premature labor.Methods The patients with gestational diabetes mellitus threatened premature delivery were divided into treatment group and control group according to the treatment method.The control group received conventional treatment+ritodrine hydrochloride injection(100 mg,intravenous drip,continuous infusion after stopping uterine contraction for 12 h)+ritodrine hydrochloride tablets(10 mg,oral,q2 h on the first day,q4 h on the second day,q6 h on the day 3-7);on the basis of control group,the treatment group was added with allylestradiol tablets(5 mg,orally,3-4 times a day).The course of treatment for both groups was 7 days.The clinical efficacy,blood glucose-related indicators,inflammatory-related indicators,pregnancy outcomes and neonatal outcomes were compared between the two groups,and safety was evaluated.Results A total of 98 cases were included in this study,including 50 cases in control group and 48 cases in treatment group.After treatment,the total clinical effective rates in treatment group and control group were 93.75％(45 cases/48 cases)and 80.00％(40 cases/50 cases),respectively,with statistically significant difference(P＜0.05).After treatment,the fasting blood glucose(FBG)levels in treatment group and control group were(5.26±0.11)and(5.28±0.17)mmol·L-1,respectively;the 2-hour postprandial blood glucose(2 h PG)levels were(6.35±0.25)and(6.42±0.24)mmol·L-1,respectively;interleukin-6(IL-6)levels were(6.49±1.06)and(7.13±1.43)pg·mL-1,respectively;IL-8 levels were(12.59±2.17)and(13.94±2.60)pg·mL-1,respectively;IL-10 levels were(12.30±2.49)and(11.09±1.95)pg·mL-1,respectively;prolonged pregnancy duration were(11.67±3.84)and(9.82±2.96)days,respectively;the proportions of vaginal delivery was 66.67％(32 cases/48 cases)and 46.00％(23 cases/50 cases),respectively;postpartum blood loss levels were(185.21±21.49)and(196.58±24.75)mL,respectively;the 1-minute Apgar scores of newborns were(9.04±0.20)and(8.86±0.35)points,respectively;the live birth rates were 97.92％(47 cases/48 cases)and 90.00％(45 cases/50 cases),respectively;the incidences of neonatal respiratory distress syndrome(NRDS)were 4.17％(2 cases/48 cases)and 20.00％(10 cases/50 cases),respectively;the incidences of apnea in premature infants were 4.17％(2 cases/48 cases)and 18.00％(9 cases/50 cases),respectively;the incidences of hematosepsis were 6.25％(3 cases/48 cases)and 14.00％(7 cases/50 cases),respectively;the incidences of neonatal pneumonia were 2.08％(1 cases/48 cases)and 6.00％(3 cases/50 cases),respectively.Except for FBG,2 h PG,live birth rate,incidences of neonatal sepsis and neonatal pneumonia,the differences in the above indicators between treatment group and control group were all statistically significant(P＜0.05,P＜0.01).The adverse drug reactions in treatment group were primarily palpitations,nausea and vomiting,and headache,while those in control group mainly included palpitations,constipation,nausea and vomiting.The incidences of adverse drug reactions in treatment group and control group were 6.25％(3 cases/48 cases)and 8.00％(4 cases/50 cases),respectively,with no statistically significant difference(P＞0.05).Conclusion Allylestrenol tablet combined with ritodrine hydrochloride tablet can effectively treat threatened preterm labor in gestational diabetes mellitus,significantly prolong gestational age,improve inflammatory responses,and optimize pregnancy and neonatal outcomes without increasing the risk of adverse drug reactions.关键词
烯丙雌醇片/盐酸利托君片/妊娠期糖尿病/先兆早产/妊娠结局/新生儿结局Key words
allylestrenol tablet/ritodrine hydrochloride tablet/gestational diabetes/threatened premature labor/pregnancy outcome/neonatal outcome分类
医药卫生引用本文复制引用
郭云霞,王宏霞,刘艳会,杨坤..烯丙雌醇联合盐酸利托君治疗妊娠期糖尿病先兆早产患者的临床研究[J].中国临床药理学杂志,2026,42(8):1064-1069,6.基金项目
山东省中医药科技基金资助项目(M2022126) （M2022126）
