中国临床药理学杂志2026，Vol.42Issue(8)：1182-1188,7.DOI:10.13699/j.cnki.1001-6821.2026.08.021
中医药调控NLRP3炎症小体治疗多囊卵巢综合征的研究进展
Research progress on the treatment of polycystic ovary syndrome by traditional Chinese medicine regulating NLRP3 inflammasome
摘要
Abstract
Polycystic ovary syndrome(PCOS),a prevalent endocrine-metabolic disorder,is characterized by hyperandrogenemia,ovulatory dysfunction,and polycystic ovarian morphology.The nucleotide-binding leucine-rich repeat(NLR)family pyrin domain containing 3(NLRP3)inflammasome,an intracellular complex composed of active-NLRP3,apoptosis-associated speck-like protein containing a CARD(ASC)and pro-cysteine aspartate specific proteinase 1(Pro-Caspase-1),is activated by stimuli such as pathogen invasion,oxidative stress,and metabolic disorders,regulating the release of pro-inflammatory cytokines including interleukin-1 β(IL-1β)and IL-18 to mediate inflammatory responses.PCOS is intricately linked to NLRP3 inflammasome activation:it triggers NLRP3 via mechanisms including ion imbalance,mitochondrial dysfunction,and metabolic product accumulation,leading to the release of pro-inflammatory factors that exacerbate ovarian inflammatory microenvironment,inhibit follicular development,and induce granulosa cell apoptosis.Concurrently,NLRP3 inflammasome activation exacerbates metabolic disorders and reproductive endocrine abnormalities by disrupting insulin signaling and promoting androgen synthesis,forming a"metabolism-inflammation-reproduction"vicious cycle.This paper systematically reviews the basic research progress of traditional Chinese medicine(TCM)in regulating NLRP3 inflammasome and deeply explores the synergistic mechanisms of TCM in anti-inflammatory and metabolic regulation within PCOS models,aiming to provide novel therapeutic strategies for PCOS.关键词
多囊卵巢综合征/NLRP3炎症小体/中医药/治疗Key words
traditional Chinese medicine/polycystic ovary syndrome/NLR family pyrin domain containing 3 inflammasome/treatment分类
医药卫生引用本文复制引用
裴重重,刘迎萍,王雁,许彩凤,郑君..中医药调控NLRP3炎症小体治疗多囊卵巢综合征的研究进展[J].中国临床药理学杂志,2026,42(8):1182-1188,7.基金项目
甘肃省科技厅基金资助项目(22JR5RA619) （22JR5RA619）
