中国临床药学杂志2026，Vol.35Issue(4)：309-315,7.DOI:10.19577/j.1007-4406.2026.04.004
基于处方前置审核系统的G6PD缺乏症患者用药安全审核体系的构建与应用
Development and implementation of an audit system based on the pre-prescription review system for medication safety in patients with glucose-6-phosphate dehydrogenase deficiency
莫惠而 1陆嫦萍 1翟青 1彭美云1
作者信息
- 1. 佛山市顺德区和祐医院药学部,佛山 528313
- 折叠
摘要
Abstract
AIM To construct an audit system based on the pre-prescription review system for medication safety in patients with glucose-6-phosphate dehydrogenase(G6PD)deficiency,aiming to standardize physician prescribing practices and ensure patient medication safety.METHODS A G6PD deficiency contraindicated medication database(including Chinese and Western medicines)was integrated and embedded into the pre-prescription review module of the Medicom PASS system.Graded alert rules were established based on drug contraindication levels(contraindicated/use with caution),and real-time prescription interception was implemented via a three-tier review mechanism.RESULTS Over 5 months of operation,the system intercepted 63 inappropriate prescriptions containing contraindicated medications(involving 19 distinct drugs),achieving a 100％alert trigger rate.Physicians subsequently adjusted medication regimens in 55.56％of these cases.The system performed each interception within 1 to 2 seconds,while the average time required for online pharmacist review was 13.01 seconds per order.Compared to the period before the implementation of the audit system based on the pre-prescription review system for medication safety,prescription review efficiency demonstrated a significant improvement.CONCLUSION Based on the pre-prescription review system,the disease-specific medication safety review framework significantly reduces medication errors in patients with G6PD deficiency.Its graded alert mechanism effectively balances medication safety with clinical flexibility,overcoming the limitations of traditional manual review.This model provides an empirical reference for hospitals to establish cost-effective and efficient medication safety systems,contributing to the optimization of pharmacist review efficiency and clinical rational medication use levels.关键词
葡萄糖-6-磷酸脱氢酶缺乏症/合理用药/用药安全/处方前置审核系统Key words
glucose-6-phosphate dehydrogenase deficiency/rational drug use/medication safety/pre-prescription review system分类
医药卫生引用本文复制引用
莫惠而,陆嫦萍,翟青,彭美云..基于处方前置审核系统的G6PD缺乏症患者用药安全审核体系的构建与应用[J].中国临床药学杂志,2026,35(4):309-315,7.
