中国内镜杂志2026，Vol.32Issue(5)：1-8,8.DOI:10.12235/E20250364
气管镜窄带成像技术联合血清赖氨酸氧化酶样蛋白4和过氧化物酶3诊断支气管肺癌的临床价值
Clinical diagnostic value of bronchoscopic narrow-band imaging combined with serum LOXL4 and PRDX3 for bronchogenic carcinoma
摘要
Abstract
Objective To explore the diagnostic value of bronchoscopic narrow-band imaging(NBI)combined with serum lysine oxidase like protein 4(LOXL4)and peroxiredoxin 3(PRDX3)for bronchogenic carcinoma.Methods From January 2024 to February 2025,107 patients with bronchogenic carcinoma admitted to hospital were considered as the bronchogenic carcinoma group.During the same period,95 patients with benign lung diseases were considered as the benign lung disease group.All patients underwent NBI examination using electronic bronchoscopy.The enzyme-linked immunosorbent assay(ELISA)method was used to detect serum LOXL4 and PRDX3.The Kappa test was used to explore the consistency between this new diagnostic method and pathological diagnosis.The receiver operating characteristic curve(ROC curve)was used to explore the efficacy of bronchoscopic NBI,LOXL4,and PRDX3 alone and in combination models for the diagnosis of bronchogenic carcinoma.Results The Kappa value of bronchoscopic NBI for the diagnosis of bronchogenic carcinoma was 0.759,which showed high consistency with the pathological diagnosis(P<0.05).Compared with the benign lung disease group,the bronchogenic carcinoma group had lower serum LOXL4 and higher PRDX3(P<0.05).The area under the curve(AUC)values for the diagnosis of bronchogenic carcinoma using bronchoscopic NBI,LOXL4,and PRDX3 alone and in combination models were 0.951,0.769,0.813,and 0.988,respectively.The AUC for the combined model was higher than those for other indicators alone(Z=2.290,Z=6.343,Z=5.720,P<0.05).The sensitivities were 96.26%,76.64%,74.77%,96.32%,and the specificities were 78.95%,74.74%,75.79%,96.87%,respectively.The diagnostic thresholds for LOXL4,PRDX3,and the combined model were 6.54 ng/mL,151.54 ng/mL,and 0.89,respectively.There was no statistically prominent difference in serum LOXL4 and PRDX3 among patients with different pathological subtypes of bronchogenic carcinoma(P>0.05).The Kappa value of bronchoscopic NBI for differential diagnosis of the pathological classification of bronchogenic carcinoma was 0.092,which had low consistency with the pathological diagnosis(P>0.05).Conclusion Bronchoscopic NBI has high diagnostic value for bronchogenic carcinoma,and the diagnostic efficiency is further improved when it is combined with serum LOXL4 and PRDX3.关键词
支气管肺癌/气管镜窄带成像技术(NBI)/赖氨酸氧化酶样蛋白4/过氧化物酶3/诊断Key words
bronchogenic carcinoma/bronchoscopic narrow-band imaging(NBI)/lysine oxidase like protein 4/peroxiredoxin 3/diagnosis分类
医药卫生引用本文复制引用
何淑梅,罗凤,郭爽..气管镜窄带成像技术联合血清赖氨酸氧化酶样蛋白4和过氧化物酶3诊断支气管肺癌的临床价值[J].中国内镜杂志,2026,32(5):1-8,8.基金项目
2025年度河北省医学科学研究课题计划(20251225) （20251225）
