中国全科医学2026，Vol.29Issue(20)：2860-2866,7.DOI:10.12114/j.issn.1007-9572.2025.0170
全国不同区域的2340例肺癌患者临床特征及基础证候分布差异研究
Research on the Differences in the Clinical Characteristics and Basic Pattern Distribution of 2 340 Lung Cancer Patients in Different Regions of China
摘要
Abstract
Background Traditional Chinese medicine(TCM)theory suggests a close relationship between syndromes and geographical regions.However,clinical research investigating regional variations in clinical characteristics and TCM syndrome distributions among lung cancer patients remains insufficient.Objective To analyze regional differences in clinical characteristics and TCM syndrome distributions among lung cancer patients across various regions in China,providing evidence to support clinical syndrome differentiation.Methods A cross-sectional survey was conducted,distributing questionnaires to outpatient or inpatient lung cancer patients from June 2020 to June 2024 in 11 hospitals:the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Longhua Hospital Affiliated with Shanghai University of Traditional Chinese Medicine,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Henan Provincial Hospital of Traditional Chinese Medicine,Henan Cancer Hospital,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,and the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine.Patients were grouped into seven geographical regions:Northeast,North China,East China,South China,Central China,Northwest,and Southwest.General characteristics among the seven regions such as age,gender,ethnicity,tumor node metastasis(TNM)staging,pathological type,treatment methods,and distribution of fundamental Traditional Chinese Medicine syndromes(lung qi deficiency syndrome,blood stasis syndrome,lung yin deficiency syndrome,etc.)were compared.Results A total of 2 340 patients with lung cancer were enrolled in this study.There were significant regional differences among seven regions of patient age,gender,ethnicity,TNM stage,pathological type,treatment modality,smoking history,chronic respiratory diseases,family history of tumors,living environment,and patient self-assessment scores(pain,quality of life,functional status,physical condition,anxiety,depression)(P<0.05).The overall frequency of basic lung cancer syndromes across the seven regions ranked from highest to lowest as follows:lung qi deficiency,blood stasis,lung yin deficiency,spleen qi deficiency,phlegm dampness,and phlegm heat syndrome,with significant regional differences(P<0.05).Specifically,the predominant syndromes were lung qi deficiency(37.11%),lung yin deficiency(33.51%),and phlegm-dampness(20.10%)in the Northeast region,lung qi deficiency(85.19%),blood stasis(72.84%),and lung yin deficiency(44.44%)in North China,lung qi deficiency(69.15%),lung yin deficiency(44.47%),spleen qi deficiency(19.15%),and blood stasis(19.15%)in East China,lung qi deficiency(58.50%),lung yin deficiency(37.00%),and phlegm dampness(21.00%)in South China,lung qi deficiency(51.51%),blood stasis(35.92%),and spleen qi deficiency(35.92%)in Central China;lung qi deficiency(74.00%),spleen qi deficiency(58.00%),and blood stasis(51.00%)in Northwest China;and blood stasis(31.34%),lung qi deficiency(28.26%),and lung yin deficiency(18.41%)in Southwest China.Conclusion Regional variations exist in the clinical characteristics and TCM syndrome distributions among lung cancer patients in China.TCM syndrome differentiation and treatment should therefore consider both geographical and individual factors to enhance clinical efficacy.关键词
肺癌/中医/证候/区域差异/临床研究Key words
Lung cancer/Traditional Chinese medicine/Syndrome/Regional differences/Clinical research分类
医药卫生引用本文复制引用
冯贞贞,周洵,刘文瑞,李建生,关徐涛,全建峰,高宏,田建辉,荣震,侯炜..全国不同区域的2340例肺癌患者临床特征及基础证候分布差异研究[J].中国全科医学,2026,29(20):2860-2866,7.基金项目
国家自然科学基金资助项目(82205313) （82205313）
河南省科技研发计划联合基金(优势学科培育类)项目(232301420071) （优势学科培育类）
河南省中医药科学研究专项课题(2022JDZX102) （2022JDZX102）
