中国比较医学杂志2026，Vol.36Issue(10)：88-98,119,12.DOI:10.3969/j.issn.1671-7856.2026.10.009
SREBP在代谢功能障碍相关脂肪性肝病的作用及靶向干预
The role of sterol regulatory element-binding proteins in metabolic dysfunction-associated steatotic liver disease and targeted interventions
摘要
Abstract
Metabolic dysfunction-associated steatotic liver disease(MASLD)represents a global health issue characterized by excessive hepatic lipid accumulation,insulin resistance,and oxidative stress.Sterol regulatory element-binding proteins(SREBP),particularly SREBP-1c and SREBP-2,are key transcriptional regulators of lipid synthesis and cholesterol metabolism.Growing evidence indicates that SREBPs play a central role in MASLD pathogenesis by modulating lipogenesis,interacting with insulin signaling,and regulating endoplasmic reticulum and oxidative stress.This review explores the role of SREBPs in MASLD pathogenesis,along with related influencing factors and therapeutic strategies,providing valuable insights for a deeper understanding of the disease mechanisms and for the development of novel SREBP-targeted treatments.关键词
SREBP/MASLD/脂质代谢/肠道菌群/昼夜节律/靶向治疗Key words
SREBP/MASLD/lipid metabolism/gut microbiota/circadian rhythm/targeted therapy分类
医药卫生引用本文复制引用
程丛丛,康晨阳,王雅媛,陈丽..SREBP在代谢功能障碍相关脂肪性肝病的作用及靶向干预[J].中国比较医学杂志,2026,36(10):88-98,119,12.基金项目
国家自然科学基金(82305401) （82305401）
湖北省自然科学基金(2023AFD140). （2023AFD140）
