中国畜牧兽医2026，Vol.53Issue(6)：2984-2993,10.DOI:10.16431/j.cnki.1671-7236.2026.06.018
乳酸菌对畜禽肠道稳态和免疫调控的研究进展
Research Progress on the Effects of Lactic Acid Bacteria on Intestinal Homeostasis and Immune Regulation in Livestock and Poultry
摘要
Abstract
The intestinal microbiota of livestock and poultry is widely regarded as an important component for maintaining the internal balance of the body and is closely related to the health and diseases of livestock and poultry.Many diseases are accompanied by the disorder of intestinal microbiota.Some probiotics are often used to maintain the stability of intestinal microecology,regulate the immune system of the body,improve the barrier function,alleviate the diseases of the body and maintain the health of the body.Among them,lactic acid bacteria,as a group of probiotics widely distributed in animal-derived foods,the gastrointestinal tract and the reproductive tract,are the most widely used probiotics.Their potential to inhibit the proliferation of harmful bacteria,promote the growth of beneficial bacteria,maintain the stability of intestinal microecology,enhance the physical barrier of the intestinal tract by up-regulating the expression of tight junction proteins,promote the secretion of mucin by goblet cells and enhance the protective effect of the mucus layer,and maintain the chemical barrier of the intestinal tract;at the same time,promote the secretion of anti-inflammatory factors and inhibit the recruitment of pro-inflammatory factors by activating immune-related pathways has been widely confirmed.Based on this,this paper systematically expounds the biological characteristics of lactic acid bacteria,the regulatory mechanism of their surface active components on the intestinal barrier function of livestock and poultry,and the regulatory effect of lactic acid bacteria on the intestinal barrier,summarizes the application status and future research directions of lactic acid bacteria in livestock production,in order to provide a reference for the further development and application of lactic acid bacteria resources,and provide a scientific basis for promoting the reduction of antibiotics in animal husbandry,green breeding and safe production.关键词
乳酸菌/宿主肠道/免疫调控Key words
lactic acid bacteria/host intestinal/immunoregulation分类
农业科技引用本文复制引用
马驰,冯小芳,郭鹏辉,郑娟善..乳酸菌对畜禽肠道稳态和免疫调控的研究进展[J].中国畜牧兽医,2026,53(6):2984-2993,10.基金项目
2025年甘肃省农业农村厅种业公关项目(ZYGG-2025-10) （ZYGG-2025-10）
兰州市科技计划项目(2024JSCX0002) （2024JSCX0002）
西北民族大学中央高校基本科研业务费项目(31920250075、31920250001) （31920250075、31920250001）
西北民族大学引进人才研究项目(xbmuyjrc202515) （xbmuyjrc202515）
兰州市指导计划项目(2024-9-271) （2024-9-271）
甘肃省高等学校人才培养质量提升项目(2024JGZD013) （2024JGZD013）
西北民族大学第二轮校级创新团队项目(10017648) （10017648）
