中国医科大学学报2026，Vol.55Issue(5)：411-415,5.DOI:10.12007/j.issn.0258-4646.2026.05.005
血管生成素样蛋白4与内脂素在急性心力衰竭患者血清中的水平及其与短期预后的关系
Levels of serum angiopoietin-like protein 4 and visfatin in patients with acute heart failure and their relationship with short-term prognosis
摘要
Abstract
Objective To evaluate levels in serum angiopoietin-like protein 4(ANGPTL4)and visfatin in patients with acute heart failure(AHF)and their relationship with short-term prognosis.Methods Ninety-seven patients with AHF treated at our hospital between September 2021 and September 2022 were selected as the observation group,and 60 patients who underwent health checkups during the same period were included as the control group.Serum ANGPTL4 and visfatin levels were detected using ELISA.Patients with AHF were followed up for 3 months after discharge and categorized into good(68 patients)and poor(29 patients)prognosis groups according to whether they had an endpoint event.We compared the data,including serum ANGPTL4 and visfatin levels,between the two groups and used logistic regression to analyze the factors influencing the prognosis of AHF,using receiver operating characteristic curves to determine the effects of serum ANGPTL4 and visfatin expression levels on patient prognosis.Results Serum ANGPTL4 and visfatin levels were significantly lower and higher,respectively,in patients with AHF compared with the control group(P<0.05).Significant differences were observed in the tumor necrosis factor α(TNF-α)and interleukin-6(IL-6)levels and New York heart association(NYHA)grade in the poor prognosis group compared with the good prognosis group(P<0.05).Serum ANGPTL4 levels were significantly lower,while serum visfatin levels were significantly higher in patients in the poor prognosis group compared with those in the good prognosis group(P<0.05).TNF-α,IL-6,ANGPTL4,visfatin,and NYHA classification were identified as risk factors affecting AHF prognosis.The area under the curve,sensitivity,and specificity of the combination of ANGPTL4 and visfatin in predicting the prognosis of patients with AHF were 0.932,93.10%,and 75.00%,respectively,which were higher than the predictive efficacy of the above indexes individually(P<0.05).Conclu-sion ANGPTL4 is low level in the serum of patients with AHF,and is a protective factor for their prognosis,while visfatin is high level in the serum of patients with AHF and is a prognostic risk factor.关键词
血管生成素样蛋白4/内脂素/急性心力衰竭Key words
angiopoietin-like protein 4/visfatin/acute heart failure分类
医药卫生引用本文复制引用
张娟,姜静,袁平年,王洋,陈康丽..血管生成素样蛋白4与内脂素在急性心力衰竭患者血清中的水平及其与短期预后的关系[J].中国医科大学学报,2026,55(5):411-415,5.基金项目
陕西省重点研发计划(2025SF-YBXM-006) （2025SF-YBXM-006）
