中国药理学通报2026，Vol.42Issue(5)：806-811,6.DOI:10.12360/CPB202508103
蛋白质肉豆蔻酰化修饰在肿瘤发生发展中的研究进展
Research progress of protein N-myristoylation in tumorigenesis and progression
摘要
Abstract
Protein N-myristoylation is an important post-translational modification catalyzed by N-myristoyltransferase(NMT),which covalently attaches myristic acid to the N-terminal glycine residue of target proteins,thereby regulating their membrane localization,stability,and biological func-tions.This review aims to summarize the molecular mechanisms of protein N-myristoylation and its role in tumor progression,analyzing the abnormal expression patterns of protein N-myristoylation in tumors,its regulation of signaling pathways and metabolism,and its interactions with other post-translational modifications.The study shows that this modifica-tion is aberrantly expressed in multiple solid tumors such as he-patocellular carcinoma,lung cancer,breast cancer,and pros-tate cancer,and participates in regulating tumor cell prolifera-tion,migration,drug resistance,and immune evasion.关键词
蛋白质肉豆蔻酰化修饰/蛋白质翻译后修饰/N-肉豆蔻酰转移酶/肿瘤/信号通路/靶向治疗Key words
protein N-myristoylation/protein translational modifications/N-myristoyltransferase/tumors/signaling path-ways/targeted therapy分类
医药卫生引用本文复制引用
赵雅然,彭倩,杜沅沁,叶一娴,吴龙达,伍师坚,韦燕飞..蛋白质肉豆蔻酰化修饰在肿瘤发生发展中的研究进展[J].中国药理学通报,2026,42(5):806-811,6.基金项目
国家自然科学基金资助项目(No 82260786) （No 82260786）
广西中医药大学研究生教育创新计划项目(No YCSW2025436) （No YCSW2025436）
