中国药理学通报2026，Vol.42Issue(5)：811-816,6.DOI:10.12360/CPB202505006
线粒体在阿尔茨海默病中的分子机制及治疗策略研究进展
Research progress on molecular mechanisms and therapeutic strategies of mitochondria in Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD),the most prevalent neu-rodegenerative disorder among the elderly,is characterized by progressive cognitive decline.Traditional AD research has pri-marily focused on amyloid-β-protein(Aβ)plaques and Tau neurofibrillary tangles.Recent studies indicate that mitochon-drial dysfunction plays a central role in the pathogenesis of AD.As the energy-supplying organelles of neurons,mitochondrial dysfunction leads to reduced ATP production,increased oxida-tive stress,and a cascade of cellular consequences that impair neuronal function,ultimately triggering neuronal death and AD symptoms.Mitochondrial dysfunction is closely linked to hall-mark AD features such as Aβ plaque deposition and hyperphos-phorylated Tau,forming a vicious cycle that accelerates neuro-degeneration.Mitochondrial dysfunction,including mitophagy,mitofission and mitofusion,and mitochondrial injury,disrupts mitochondrial morphology maintenance and quality control,po-tentially serving as a key factor in AD neuropathology.This re-view examines the interaction mechanisms between mitochon-dria and AD,as well as drugs targeting mitochondria for AD treatment,aiming to provide new paradigms for developing pre-cision intervention strategies against AD.关键词
阿尔茨海默病/线粒体/线粒体自噬/线粒体损伤/线粒体裂变与融合/靶向治疗Key words
Alzheimer's disease/mitochondria/mitochon-drial autophagy/mitochondrial damage/mitochondrial fission and fusion/targeted therapy分类
医药卫生引用本文复制引用
张浩杰,艾启迪,杨岩涛,刘莎莎,梁金萍,曾璇,王汉隆,李淑琴,黄艳婷,楚世峰,陈乃宏..线粒体在阿尔茨海默病中的分子机制及治疗策略研究进展[J].中国药理学通报,2026,42(5):811-816,6.基金项目
国家自然科学基金资助项目(No 82130109,U2202214) （No 82130109,U2202214）
湖南省自然科学基金项目(No 2023JJ60471) （No 2023JJ60471）
湖南省中医药管理局科研课题一般项目(No B2024004) （No B2024004）
长沙市妇幼保健院2023年度院级科研重点项目(No 202329-2) （No 202329-2）
湖南中医药大学生物工程重点学科([2018]No 3) （[2018]No 3）
