中国药理学通报2026，Vol.42Issue(5)：817-824,8.DOI:10.12360/CPB202511061
携载细胞外囊泡水凝胶在伤口愈合中的构建策略与应用前景
Fabrication strategies and application prospects of hydrogels carrying extracellular vesicles in wound healing
摘要
Abstract
Effective treatment of complex wounds is a major clinical challenge.Extracellular vesicles(EVs)have shown great potential in promoting tissue repair,modulating immune responses,and accelerating wound healing,but they are easily cleared rapidly in vivo,limiting their efficacy.Hydrogels can ef-fectively protect EVs and prolong their retention time at wound sites,achieving intelligent and controlled release of EVs in re-sponse to microenvironmental signals such as pH,enzymes,or reactive oxygen species(ROS),providing an ideal solution for targeted and sustained delivery of EVs.This article reviews the mechanisms by which EVs from different sources promote wound healing,strategies for constructing their smart respon-sive carrier systems,and their applications in complex wounds.关键词
细胞外囊泡/水凝胶/智能响应/伤口愈合/复杂伤口/再生医学Key words
extracellular vesicles/hydrogel/intelligent re-sponse/wound healing/complex wounds/regenerative medi-cine分类
医药卫生引用本文复制引用
杨艳伟,王上,霍利月,张小琳,张钰蓓,汪雪峰..携载细胞外囊泡水凝胶在伤口愈合中的构建策略与应用前景[J].中国药理学通报,2026,42(5):817-824,8.基金项目
国家自然科学基金资助项目(No 81871243) （No 81871243）
江苏省社会发展项目(No BE2017697) （No BE2017697）
江苏省"六大人才高峰"项目(No WSN-009) （No WSN-009）
镇江市中医妇科病临床医学研究中心开放课题(No SS202204-KFB02) （No SS202204-KFB02）
