中国药理学通报2026，Vol.42Issue(5)：825-830,6.DOI:10.12360/CPB202512006
中药活性成分靶向肠道菌群代谢物调控肿瘤的研究进展
Research progress on regulation of gut microbiota metabolites by active components of traditional Chinese medicine in cancer
摘要
Abstract
Malignant tumors have become a major global health threat.Conventional therapies such as chemotherapy and radio-therapy are limited in clinical application and efficacy improve-ment due to prevalent limitations including drug resistance,poor targeting,and severe toxic side effects.This article sys-tematically reviews the functional characteristics of traditional Chinese medicine(TCM)active ingredients in regulating gut microbiota and their metabolites,as well as the impact of this regulatory network on tumor progression,aiming to provide new directions for the research on TCM active ingredients in anti-tumor therapy.Through the review,it is found that TCM active ingredients can effectively reshape the gut microbiota ecology and significantly alter the levels and composition of microbial metabolites in the host.As key signaling molecules,these me-tabolites can directly or indirectly inhibit the proliferation and metastasis of tumor cells and improve the tumor microenviron-ment through multiple pathways,such as regulating the body's immune-inflammatory response,maintaining intestinal barrier function,and affecting energy metabolism.Therefore,in-depth clarification of the mechanism by which TCM active ingredients regulate tumor progression through gut microbiota and their me-tabolites will lay a theoretical foundation for the future develop-ment of novel strategies for tumor prevention and treatment based on microbiota regulation.关键词
中药活性成分/代谢物/肠道菌群/肿瘤/免疫微环境/治疗应用Key words
active ingredients of traditional Chinese medicine/metabolites/intestinal flora/tumor/immune microenviron-ment/therapeutic applications分类
医药卫生引用本文复制引用
裴雨荷,赵明慧,张静鑫,相程文,张岚,史建红,李靖华,秦岩..中药活性成分靶向肠道菌群代谢物调控肿瘤的研究进展[J].中国药理学通报,2026,42(5):825-830,6.基金项目
国家自然科学基金资助项目(No 82103181) （No 82103181）
河北省自然科学基金资助项目(No H2023201018) （No H2023201018）
河北省临床医学优秀人才项目(No ZF2025257) （No ZF2025257）
河北大学附属医院院内基金项目(No 2023ZA01) （No 2023ZA01）
保定市科技计划资助项目(No 2463P025) （No 2463P025）
河北省研究生创新能力培养资助项目(No CXZZSS2025010,HBU2026SS013) （No CXZZSS2025010,HBU2026SS013）
