中国药理学与毒理学杂志2026，Vol.40Issue(4)：290-301,12.DOI:10.3867/j.issn.1000-3002.2026.08860
药物转运体介导的药物-药物相互作用研究进展
Advances in research on drug-drug interactions mediated by drug transporters:a review
刘勇 1刘鸿君 1王倩1
作者信息
- 1. 汇智和源生物技术(苏州)有限公司,江苏 苏州 215332
- 折叠
摘要
Abstract
Drug transporters are key membrane proteins that regulate the disposition of numerous drugs within the body,and transporter-mediated drug-drug interactions(DDIs)directly impact drug pharmacokinetics and clinical medication safety,representing a core component of evaluation in both drug development and clinical practice.Major global regulatory agencies have issued specific guide-lines to standardize the evaluation of DDIs risks involving key transporters.This review summarizes the current research landscape of transporter-mediated DDIs,with a focus on interpreting the differences in core requirements and regulatory expectations outlined in the guidelines of the three major regulatory authorities—the Food and Drug Administration(FDA),European Medicines Agency(EMA)and Phar-maceuticals and Medical Devices Agency(PMDA).The advances in the application of in vitro-in vivo extrapolation(IVIVE)strategies are outlined,major challenges to IVIVE are underscored,and risk man-agement strategies are recommended.Current challenges in this field include a poor understanding of inter-individual variability,inaccuracy in IVIVE,and a lack of data from special populations.Future research should focus on optimizing experimental models and predictive methodologies and advancing the understanding of metabolic-transport interplay in order to provide evidence for risk management in drug development and precision medication.关键词
药物转运体/药物-药物相互作用/体外-体内外推/生理药代动力学模型/临床用药安全/药代动力学/生物标志物Key words
drug transporters/drug-drug interactions/in vitro-in vivo extrapolation/physiologically based pharmacokinetic models/clinical medication safety/pharmacokinetics/biomarkers分类
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刘勇,刘鸿君,王倩..药物转运体介导的药物-药物相互作用研究进展[J].中国药理学与毒理学杂志,2026,40(4):290-301,12.
