中国药业2026，Vol.35Issue(11)：6-9,4.DOI:10.3969/j.issn.1006-4931.2026.11.002
药学服务干预对首发精神分裂症患者用药依从性的影响
Effect of Pharmaceutical Care Intervention on Medication Adherence in Patients with First-Episode Schizophrenia
摘要
Abstract
Objective To investigate the effect and factors of pharmaceutical care intervention on medication adherence in patients with first-episode schizophrenia(SCH).Methods A total of 80 patients with first-episode SCH admitted to the hospital from January 2020 to June 2023 were selected and randomly divided into the control group and the study group by the random number table method,with 40 cases in each group.The patients in the two groups were treated with Risperidone Orally Disintegrating Tablets.On this basis,the patients in the control group received routine intervention,while the patients in the study group received pharmaceutical care intervention.The patients' medication adherence in two groups was compared,the influencing factors of medication adherence were analyzed by the univariate analysis,and the risk factors and the protective factors for medication adherence were analyzed by the binary Logistic regression analysis.Results The overall medication adherence rate in the study group was significantly higher than that in the control group(92.50%vs.65.00%,P＜0.03).The influencing factors of medication adherence included intervention methods,age,disease-related knowledge,trust in physicians,family support,monthly income,medication types,daily medication frequency,and regular follow-up.Among them,age≥60 years old,lack of disease-related knowledge,and routine intervention were risk factors for medication adherence in patients with first-episode SCH(P＜0.05),while family support was a protective factor for medication adherence in patients with first-episode SCH(P＜0.05).Conclusion Pharmaceutical care intervention can improve medication adherence in patients with first-episode SCH,which is related to age,disease-related knowledge,whether to conduct the pharmaceutical care intervention,and whether there is family support.关键词
药学服务干预/精神分裂症/用药依从性Key words
first-episode/schizophrenia/pharmaceutical care intervention/medication adherence分类
医药卫生引用本文复制引用
杨淇茗,袁晓燕,陈彦清,张晓庆,罗刚..药学服务干预对首发精神分裂症患者用药依从性的影响[J].中国药业,2026,35(11):6-9,4.基金项目
四川省预防医学会第二届静脉药物配制科研(孵化)项目[川预学-静配-2020-005]. （孵化）
