中国中医急症2026，Vol.35Issue(5)：503-510,8.DOI:10.3969/j.issn.1004-745X.2026.05.002
中药治疗肝衰竭肠源性内毒素血症疗效的Meta分析
Meta-analysis on the Efficacy of Traditional Chinese Medicine in the Treatment of Intestinal Endotox-emia in Liver Failure
摘要
Abstract
Objective:To systematically evaluate the efficacy of traditional Chinese medicine(TCM)in the treat-ment of intestinal endotoxemia in patients with liver failure.Methods:Databases including CNKI,Wanfang Data,VIP,PubMed,Web of Science and the Cochrane Library were searched electronically from inception to November 12,2025.RevMan 5.3 software was used for statistical analysis.Results:A total of 20 randomized controlled trials(RCTs)were included.Meta-analysis results showed that there were statistically significant differences between the TCM compound intervention group and the control group in the number of clinically effective cases[OR=2.29,95％CI(1.77,2.96),P＜0.000 01]and the number of non-effective cases[OR=0.33,95％CI(0.24,0.46),P＜0.000 01].Additionally,the Chinese herbal compound significantly reduced the levels of interleukin-6[SMD=-1.29,95％CI(-1.83,-0.76),P＜0.000 01],tumor necrosis factor-α[SMD=-1.37,95％CI(-1.88,-0.85),P＜0.000 01],endotoxin[SMD=-1.01,95％CI(-1.54,-0.47),P=0.000 2],alanine aminotransferase[SMD=-0.93,95％CI(-1.39,-0.47),P＜0.000 1],aspartate aminotransferase[SMD=-1.26,95％CI(-1.73,-0.79),P＜0.000 01],total bilirubin[OR=-1.09,95％CI(-1.50,-0.68),P＜0.000 01],diamine oxidase[(SMD=-1.85,95％CI(-2.66,-1.04),P＜0.000 01],interleukin-1[SMD=-1.07,95％CI(-1.51,-0.64),P＜0.000 01],interleukin-8[SMD=-2.24,95％CI(-2.93,-1.55),P＜0.000 01],urinary lactulose/mannitol ratio[MD=-0.18,95％CI(-0.20,-0.16),P＜0.000 01],TCM syndrome score[SMD=-1.74,95％CI(-2.47,-1.01),P＜0.000 01],D lactate[SMD=-1.84,95％CI(-2.59,-1.09),P＜0.000 01],and blood ammonia[SMD=-1.78,95％CI(-2.73,-0.82),P=0.000 3],while increasing the levels of prothrombin activity[SMD=1.36,95％CI(0.90,1.81),P＜0.000 01]and albumin[SMD=0.20,95％CI(0.07,0.33),P=0.002].All these differences were statistically significant.Conclusion:For patients with liver failure complicated with intestinal endotoxemia,TCM intervention can improve the total clinical effective rate,reduce the risk of ineffectiveness,protect liver function and inhibit the elevation of inflammatory indi-cators.关键词
肠源性内毒素血症/肝衰竭/中药/疗效/Meta分析Key words
Intestinal endotoxemia/Liver failure/Chinese materia medica/Efficacy/Meta-analysis分类
医药卫生引用本文复制引用
冯荣,史英,冯阳,单瑞琪,曾大凌,刘金响..中药治疗肝衰竭肠源性内毒素血症疗效的Meta分析[J].中国中医急症,2026,35(5):503-510,8.基金项目
国家自然科学基金项目(82204877) （82204877）
陕西省中医药科技创新提质扩能计划(TZKN-CXPT-03) （TZKN-CXPT-03）
