中国中医眼科杂志2026，Vol.36Issue(6)：522-525,534,5.DOI:10.13444/j.cnki.zgzyykzz.2026.06.004
磁共振扩散张量成像对甲状腺相关眼病患者的视神经定量分析
Quantitative Analysis of Optic Nerve in Patients with Thyroid Eye Disease Using Mag-netic Resonance Diffusion Tensor Imaging
摘要
Abstract
OBJECTIVE To observe the quantitative analysis of the optic nerve in patients with thyroid eye disease(TED)using magnetic resonance diffusion tensor imaging(DTI).METHODS A total of 21 patients(42 eyes)with TED who were treated at Eye Hospital,China Academy of Chinese Medical Sciences from November 2023 to September 2024 were enrolled as the TED group,and 29 healthy volunteers(58 eyes)were enrolled as the control group.Orbital DTI scanning was performed in both groups.Fractional anisotropy(FA),apparent diffusion coefficient(ADC),mean diffusivity(MD),radial anisotropy(RA),and optic nerve diameter were measured and compared between the two groups.Correlations between these measurements and TED were analyzed.RESULTS(1)Optic nerve DTI imaging findings:On axial T1-weighted imaging(T1WI),the unilateral optic nerve of TED patients showed ill-defined boundary,the surrounding extraocular muscles were obviously fusiform thickened,and soft tissue swelling caused compression on the optic nerve;The optic nerve of healthy volunteers presented natural course and sharp boundary.(2)Comparison of DTI parameters:ADC and MD values of the optic nerve were significantly higher,and optic nerve diameter was significantly lower in the TED group than in the control group(tADC=4.749,P=0.029;tMD=43.173,toptic nerve=22.758,both P=0.000).There were no significant differences in FA or RA values between the two groups(all P>0.05).(3)Correlation between optic nerve DTI measurements and TED:Bilateral optic nerve ADC and MD values were positively correlated with TED(rADC=0.218,P=0.029;rMD=0.553,P=0.000);axial values of bilateral optic nerves were negatively correlated with TED(r=-0.434,P=0.000).Bilateral optic nerve MD values were positively correlated with gender(r=0.209,P=0.037),while axial values of bilateral optic nerves were negatively correlated with gender(r=-0.268,P=0.007).All of the above differences were statistically significant.CONCLUSIONS Measurement of DTI parameters can provide important reference for quantitative evaluation of optic nerve injury in patients with TED.关键词
磁共振扩散张量成像/甲状腺相关性眼病/视神经Key words
magnetic resonance diffusion tensor imaging/thyroid eye disease/optic nerve分类
医药卫生引用本文复制引用
王东,吕喆,班景飞,高倩,赫义兰,胡津赫,张春柱..磁共振扩散张量成像对甲状腺相关眼病患者的视神经定量分析[J].中国中医眼科杂志,2026,36(6):522-525,534,5.基金项目
中国中医科学院眼科医院中央高水平医院项目(GSP5-87) （GSP5-87）
