中华耳科学杂志2026，Vol.24Issue(6)：598-603,6.DOI:10.3969/j.issn.1672-2922.2026.06.019
线粒体动力学及线粒体自噬在感音神经性耳聋分子机制中的作用
The role of mitochondrial dynamics and mitophagy in molecular mechanisms of sensorineural hearing loss
摘要
Abstract
Mitochondria are crucial for the body's energy metabolism.Mitochondrial dysfunction can lead to abnormal cellular energy metabolism,causing cell death or functional decline,which can then lead to fundamental pathological changes in certain diseases.Currently,the academic community generally believes that mitochondrial damage may be one of the main pathogenic mechanisms of sensorineural hearing loss(SNHL).Numerous studies have shown that mitochondrial dysfunction,such as mitochondrial dynamics disorders,autophagy impairment,or mitochondrial DNA mutations,can result in accumulation of reactive oxygen species,which,through oxidative stress,can damage cells in the auditory conduction pathway,such as auditory nerves and cochlear hair cells,ultimately progressing to SNHL.Presbycusis,the most common type of SNHL,is closely associated with functional decline of the mitochondrial quality control system,manifested as mitochondrial dynamics imbalance and reduced autophagy.This article aims to introduce and summarize the research progress on the mitochondrial quality control system in SNHL,with particular emphasis on presbycusis.关键词
线粒体自噬/线粒体动力学/氧化应激/感音神经性耳聋/老年性耳聋Key words
mitochondrial autophagy/mitochondrial dynamics/oxidative stress/sensorineural hearing loss/presbycusis引用本文复制引用
周逸云,王喜悦,孙捷..线粒体动力学及线粒体自噬在感音神经性耳聋分子机制中的作用[J].中华耳科学杂志,2026,24(6):598-603,6.基金项目
深圳市福田区卫生健康系统科研项目(FTWS2022017) （FTWS2022017）
