中华临床免疫和变态反应杂志2026，Vol.20Issue(2)：129-136,8.DOI:10.3969/j.issn.1673-8705.2026.02.008
益生菌通过调节肠道菌群干预过敏性疾病的研究进展
Advances in the use of probiotics for allergic diseases through gut microbiota modulation
摘要
Abstract
Allergic diseases are disorders in which the body,mediated by immunoglobulin E(IgE),exhibits abnormal immune responses against antigens.Their pathogenesis is closely related to the excessive acti-vation of type 2 immune responses and the imbalance of immune tolerance.The gut microbiota,as the core component of the mucosal immune system,dynamically regulates the systemic immune homeostasis through mechanisms such as the"gut-skin axis"and"gut-lung axis".Its disorder is a key factor in inducing and ac-celerating the allergic process.Probiotics,as an adjunctive treatment for allergic diseases,mainly exert their effects through multiple target mechanisms such as reshaping the structure of the gut microbiota,enhancing the intestinal barrier function,regulating the metabolic products of the microbiota,and balancing the Th1/Th2 im-mune responses.This article systematically elaborates on the correlation between gut microbiota imbalance and the progression of allergic diseases,focusing on the immunoregulatory role therein and the therapeutic potential of probiotics in restoring gut microbiota homeostasis to regulate disease progression.关键词
肠道菌群/过敏性疾病/益生菌/发病机制Key words
gut microbiota/allergic diseases/probiotics/pathogenesis引用本文复制引用
侯新晖,王倩,张瑾,梁俊琴..益生菌通过调节肠道菌群干预过敏性疾病的研究进展[J].中华临床免疫和变态反应杂志,2026,20(2):129-136,8.基金项目
新疆维吾尔自治区自然科学基金杰出青年科学基金(2022D01E81) （2022D01E81）
新疆维吾尔自治区天山英才青年科技拔尖人才项目(2022TSYCCX0109) （2022TSYCCX0109）
新疆第二医学院科研项目-自然科学(ZR202557) Natural Science Foundation of Xinjiang Uygur Autonomous Region Distinguished Young Scholars(2022D01E81) （ZR202557）
Tianshan Talent Fund Project of Xinjiang Uygur Autonomous Region-Youth Science and Technology Talents(2022TSYCCX0109) （2022TSYCCX0109）
Xinjiang Second Medical University Scientific Research Pro-jects-Natural Science(ZR202557) （ZR202557）
