浙江大学学报（医学版）2026，Vol.55Issue(3)：278-282,5.DOI:10.3724/zdxbyxb-2025-0806
经支气管镜检查诊断以支气管内膜结核为表现的围产期结核病一例
Perinatal tuberculosis presenting as endobronchial tuberculosis diagnosed by bronchoscopy:a case report
吴沪军 1林燕芬 2陶孝芬 1吴磊1
作者信息
- 1. 浙江大学医学院附属儿童医院内镜中心 儿童少年健康与疾病国家临床医学研究中心,浙江 杭州 310052
- 2. 浙江大学医学院附属儿童医院呼吸科 儿童少年健康与疾病国家临床医学研究中心,浙江 杭州 310052
- 折叠
摘要
Abstract
A 3-month and 17-day-old male infant presented with a 4-week history of cough and was initially diagnosed with pneumonia.Despite over 20 days of antibiotic therapy(including ceftriaxone,piperacillin-tazobactam,and vancomycin),his symptoms did not improve.Chest CT revealed worsening pulmonary infiltrates.Bronchoscopic findings revealed stenosis of the left main bronchus with mucosal erosion,granuloma,and caseous necrosis.Rapid on-site evaluation of bronchoalveolar lavage fluid demonstrated positivity on acid-fast staining.Together with positive T-SPOT and high-throughput sequencing results for Mycobacterium tuberculosis,the infant was diagnosed with perinatal endobronchial tuberculosis.The infant was started on an HRZLzd anti-tuberculosis regimen(isoniazid 10 mg·kg-¹·d-1 intravenous infusion,rifampicin 12.5 mg·kg-¹·d-1 orally,pyrazinamide 30 mg·kg-¹·d-1 orally,and linezolid 10 mg·kg-¹·d-1 intravenous infusion).After one month of treatment,his clinical symptoms and pulmonary imaging findings markedly improved.关键词
围产期结核病/支气管镜检查/支气管内膜结核/病例报告Key words
Perinatal tuberculosis/Bronchoscopy/Endobronchial tuberculosis/Case report分类
医药卫生引用本文复制引用
吴沪军,林燕芬,陶孝芬,吴磊..经支气管镜检查诊断以支气管内膜结核为表现的围产期结核病一例[J].浙江大学学报（医学版）,2026,55(3):278-282,5.
