基于大样本健康调研数据库分析代谢综合征及其组分与痛风发病的相关性
Association of metabolic syndrome and its components with gout:an analysis based on a large-scale health survey database
摘要
Abstract
Objective:To investigate the association of metabolic syndrome(MetS)and its components with gout.Methods:This study utilized data from 28 130 adults aged≥18 years in the National Health and Nutrition Examination Survey(NHANES)2007-2018,among whom 1279 were identified as gout patients.Logistic regression was used to assess the associations of MetS and its components with gout.Restricted cubic spline(RCS)models were employed to examine non-linear dose-response relationships between metabolic indicators and gout.Subgroup analyses were performed by age,sex,and body mass index(BMI),with interaction effects evaluated using the Wald test by including multiplicative interaction terms in the logistic regression models.Results:The prevalence of MetS was substantially higher in individuals with gout than in those without(66.9%vs.33.3%).After adjusting for age,sex,BMI,smoking,and alcohol consumption,MetS was independently associated with gout(OR=2.55,95%CI:1.55-4.20,P<0.01),with central obesity(OR=2.44,95%CI:1.55-3.85,P<0.01)and hypertension(OR=1.70,95%CI:1.04-2.78,P<0.05)showing the strongest associations.RCS analysis revealed J-shaped associations for BMI and fasting glucose,accelerating positive associations for waist circumference,mean systolic blood pressure,and triglyceride levels,and U-shaped associations for mean diastolic blood pressure and low-density lipoprotein cholesterol(LDL-C)levels(all P<0.05).High-density lipoprotein cholesterol(HDL-C)showed a significant non-linear association,with the OR value of gout generally decreasing as HDL-C levels increased(P<0.05).Subgroup analyses indicated that the association of MetS with gout was significantly stronger in females than that in males(OR:5.07 vs.2.34,interaction P<0.05),and the association of diabetes with gout was more pronounced in those aged≥50 years(OR=4.58)and in non-obese individuals(OR=5.21)(both interaction P<0.01).Conclusion:MetS is independently associated with gout,exhibiting significant non-linear dose-response characteristics and population heterogeneity.关键词
痛风/代谢综合征/危险因素/剂量-反应关系/美国国家健康与营养调查/横断面研究Key words
Gout/Metabolic syndrome/Risk factor/Dose-response relationship/National Health and Nutrition Examination Survey/Cross-sectional study分类
医药卫生引用本文复制引用
李建斌,刘维..基于大样本健康调研数据库分析代谢综合征及其组分与痛风发病的相关性[J].浙江大学学报（医学版）,2026,55(4):311-320,10.基金项目
重大疑难疾病中西医临床协作项目(ZDYN-2024-B-038) （ZDYN-2024-B-038）
天津市南开区中医药传承创新发展示范试点项目(20240204011) （20240204011）
国家中医药管理局中西医结合与少数民族医药司政府采购服务项目(2023382) （2023382）
全国名老中医药专家传承工作室建设项目This study was supported by Major Difficult Diseases Integrated Traditional Chinese and Western Medicine Clinical Collaboration Project(ZDYN-2024-B-038),Tianjin Nankai District Traditional Chinese Medicine Inher-itance Innovation and Development Demonstration Pilot Project(20240204011),Government Procurement Service Project of the Department of Integrated Traditional Chinese and Western Medicine and Ethnic Medicine of the National Administration of Traditional Chinese Medicine(2023382),and National Famous Traditional Chinese Medicine Expert Inheritance Studio Construction Project （ZDYN-2024-B-038）
