针灸临床杂志2026，Vol.42Issue(5)：12-18,7.DOI:10.19917/j.cnki.1005-0779.026083
内热针联合桂枝芍药知母汤治疗强直性脊柱炎随机对照研究
Randomized Controlled Trial of Neire Acupuncture Combined with Guizhi Shaoyao Zhimu Decoction in Treatment of AS
摘要
Abstract
Objective:To observe the clinical efficacy of Neire acupuncture(acupuncture technique for warming the deep tissue of the lesions)combined with Guizhi Shaoyao Zhimu Decoction in treatment of ankylosing spondylitis(AS).Methods:A total of 90 patients with AS were randomly divided into the control group,the treatment group 1,and the treatment group 2,with 30 patients in each group.All patients received basic treatment.The control group received Celecoxib Capsule;on which basis,the treatment group 1 was treated with Guizhi Shaoyao Zhimu Decoction orally,and the treatment group 2 was treated with Nere acupuncture and Guizhi Shaoyao Zhimu Decoction.Each group was treated for one 4-week course.After one course,the clinical efficacy and changes in ESR,CRP,IL-6,and the scores of back pain VAS,morning stiffness VAS,Schober test,Keitel functional test,and TCM symptoms were compared among the three groups.Results:The total effective rate was 56.67％(17/30)in the the control group,70.00％(21/30)the in the treatment group 1,and 96.67％(29/30)in the treatment group 2.Both treatment groups showed significantly higher total effective rates compared with the control group,and the treatment group 2 was significantly higher than the treatment group 1(P＜0.05).After the treatment,all three groups showed significant improvements in ESR,CRP,IL-6,and the scores of back pain VAS,morning stiffness VAS,Schober test,Keitel functional test,and TCM symptoms compared with their respective baseline values(P＜0.05);the improvements were more significant in the treatment group 1 and the treatment group 2 compared with the control group(P＜0.05),and the treatment group 2 demonstrated significantly superior improvements compared with the treatment group 1(P＜0.05).Conclusion:Neire acupuncture combined with Guizhi Shaoyao Zhimu Decoction not only improves spinal joint range of motion and alleviates clinical symptoms but also reduces ESR,CRP,and IL-6,thereby ameliorating inflammatory status in treatment of AS.This approach demonstrates significant efficacy with simultaneous management of symptoms and underlying pathology,and is safe in application.关键词
强直性脊柱炎/内热针/桂枝芍药知母汤Key words
Ankylosing spondylitis/Internal heat needling/Guizhi Shaoyao Zhimu Decoction分类
医药卫生引用本文复制引用
吴冠楠,刘丹,王骞,王银宁,杨世刚,贺璞玉,宋秀娟..内热针联合桂枝芍药知母汤治疗强直性脊柱炎随机对照研究[J].针灸临床杂志,2026,42(5):12-18,7.基金项目
宁夏回族自治区卫生健康科研项目,编号:2025-NWQP-B062. （）
