针灸临床杂志2026，Vol.42Issue(5)：104-109,6.DOI:10.19917/j.cnki.1005-0779.026097
基于SDF-1α/CXCR4通路探究针灸治疗对脊髓损伤作用的研究进展
Research Progress on Role of Acupuncture in SCI Based on SDF-1α/CXCR4 Pathway
摘要
Abstract
Spinal cord injury(SCI)is a highly disabling neurological disorder whose pathological mechanisms involve primary mechanical damage as well as complex secondary processes,including inflammatory cascades,oxidative stress,and glial scar formation.Recent studies have shown that acupuncture can modulate the spinal cord microenvironment through multiple targets and pathways,demonstrating considerable potential for neural repair.Among these mechanisms,the stromal cell-derived factor-1α(SDF-1α)/C-X-C chemokine receptor 4(CXCR4)signalling pathway has attracted increasing attention as a key regulatory axis.This study systematically summarizes the mechanisms by which acupuncture promotes spinal cord repair via regulation of the SDF-1α/CXCR4 pathway,including enhancement of stem cell migration and homing,improvement of the inflammatory microenvironment,and facilitation of neuro-regeneration and synaptic remodelling.Future studies should focus on the precise optimization of acupuncture parameters,the potential risks associated with excessive activation of SDF-1α,and mechanistic validation through multi-technique approaches.Further in-depth investigation into the spatiotemporal specificity of acupuncture-mediated regulation of the SDF-1α/CXCR4 pathway,as well as its synergistic effects with traditional Chinese medicinal,electrical stimulation,and other therapies,may provide novel strategies for the precision treatment of SCI.关键词
脊髓损伤/针灸/SDF-1α/CXCR4通路/作用机制/综述Key words
Spinal cord injury/Acupuncture/SDF-1α/CXCR4 pathway/Mechanism of action/Review分类
医药卫生引用本文复制引用
马腾飞,卢童,李晓静,刘丹,高莹,王海荣..基于SDF-1α/CXCR4通路探究针灸治疗对脊髓损伤作用的研究进展[J].针灸临床杂志,2026,42(5):104-109,6.基金项目
国家自然科学基金青年项目,编号:82104998 （）
国家中医针灸临床医学研究中心开放课题,编号:NCRCOP2024015. （）
