针灸临床杂志2026，Vol.42Issue(5)：110-114,5.DOI:10.19917/j.cnki.1005-0779.026098
基于神经-内分泌-免疫网络探讨针刺治疗纤维肌痛综合征的作用机制
Action Mechanism Exploration of Acupuncture in Treating Fibromyalgia Syndrome Based on Neuro-Endocrine-Immune Network
摘要
Abstract
Fibromyalgia syndrome(FMS)has a high prevalence and seriously affects patients' quality of life.Acupuncture has been shown to be an effective treatment for FMS,significantly relieving pain and improving emotional disorders and somatic symptoms.Research indicates that the therapeutic effects of acupuncture in FMS are closely related to its regulation of the neuroendocrineimmune network.This study summarizes the modulatory mechanisms of acupuncture in treating FMS,including inhibition of microglial activation,regulation of brainderived neurotrophic factor(BDNF)expression,protection against peripheral small fiber neuropathy,modulation of the hypothalamicpituitaryadrenal(HPA)axis,and regulation of cytokines,inflammatory signaling pathways,and gut microbiota.The aim is to provide a theoretical basis for understanding the mechanisms of acupuncture in treating FMS and to guide future clinical research.关键词
纤维肌痛综合征/针刺/神经-内分泌-免疫Key words
Fibromyalgia syndrome/Acupuncture/Neuro-endocrine-immune分类
医药卫生引用本文复制引用
张宇宸,高垣,崔欢,唐羚翔,沈卫东..基于神经-内分泌-免疫网络探讨针刺治疗纤维肌痛综合征的作用机制[J].针灸临床杂志,2026,42(5):110-114,5.基金项目
上海市科学技术委员会"科技创新行动计划"医学创新研究专项,编号:23Y11922100 （）
上海市健康科普专项计划,编号:JKKPZX-2024-A10. （）
