浙江农业学报2026，Vol.38Issue(5)：876-885,10.DOI:10.3969/j.issn.1004-1524.20250568
山茱萸提取物缓解小鼠急性肾损伤的功能活性评价
Evaluation of the functional activity of Cornus officinalis extract in alleviating acute kidney injury in mice
摘要
Abstract
To investigate the potential mechanism by which Cornus officinalis extract alleviates acute kidney injury,male C57BL/6J mice were selected.An acute kidney injury model was established in mice via intraperitoneal injec-tion of gentamicin.The mice were divided into a normal control group,a model group,and a Cornus officinalis ex-tract intervention group.Body weight,organ coefficients,serum creatinine and urea nitrogen concentrations,and in-flammatory cytokine mass concentrations were measured.Renal histopathological changes were observed by tissue sectioning,and the composition of the intestinal flora was analyzed.The results showed that,compared with the mod-el group,the rate of body weight change was lower in the Cornus officinalis extract group;serum creatinine and urea nitrogen concentrations were significantly reduced;IL-6 and TNF-α mass concentrations were significantly decreased,while IL-10 mass concentration was significantly increased;pathological injuries such as renal tubular epithelial cell necrosis,inflammatory infiltration,and fibrosis were significantly alleviated;the abundance of beneficial bacteria in the intestine increased,while the abundance of harmful bacteria decreased.The results indicate that Cornus officina-lis extract can exert a protective effect on acute kidney injury by regulating inflammatory responses and improving the intestinal microecology.This study elucidates the effects of Cornus officinalis extract on acute kidney injury from his-tological,immunological,and microbiological perspectives,providing a reference for the functional evaluation and precise application of Cornus officinalis extract.关键词
山茱萸提取物/急性肾损伤/肾功能/炎症因子/肠道菌群Key words
Cornus officinalis extract/acute kidney injury/renal function/inflammatory factor/gut microbiota分类
医药卫生引用本文复制引用
江豪,周万怡,陶文扬,王梦竹,邢建荣,杨颖,曾垂省..山茱萸提取物缓解小鼠急性肾损伤的功能活性评价[J].浙江农业学报,2026,38(5):876-885,10.基金项目
浙江省"尖兵领雁+X"科技计划(2025C01101) （2025C01101）
