中山大学学报（医学科学版）2026，Vol.47Issue(3)：419-428,10.DOI:10.11714/jsysu.med.YX20260008
菌群-肠-脑轴在酒精性脑损伤中的研究进展
Research Advances on the Microbiota-gut-brain Axis in Alcohol-related Brain Injury
摘要
Abstract
Chronic excessive alcohol consumption is a major global public health concern that severely endangers human health.Excessive alcohol intake disrupts the functions of multiple organs and systems in the human body through diverse mechanisms.The alcohol-sensitive microbiota-gut-brain axis plays a critical role in maintaining systemic homeostasis,immune maturation,and endocrine metabolism.Chronic excessive alcohol consumption not only alters the composition of the gut microbiota and the levels of its metabolites,but also compromises intestinal barrier integrity,increases intestinal permeability,and allows harmful metabolites to enter the systemic circulation,thereby triggering a variety of diseases including alcohol-related brain injury.Alcohol-related brain injury is one of the most severe consequences of unrecognized or inadequately treated alcohol use disorder(AUD),which can lead to extensive neuronal damage and neurocognitive dysfunction.Although the potential role of the microbiota-gut-brain axis in alcohol-related brain injury has been proposed,the exact underlying mechanisms have not yet been fully elucidated.Therefore,in this review,we systematically analyze the associations among chronic excessive alcohol consumption,the microbiota-gut-brain axis,and alcohol-related brain injury,and explore the potential mechanisms underlying alcohol-induced brain damage via this axis.关键词
酗酒/菌群-肠-脑轴/酒精性脑损伤/肠道菌群失调/干预措施Key words
chronic excessive alcohol consumption/microbiota-gut-brain axis/alcohol-related brain injury/gut dysbiosis/interventions分类
医药卫生引用本文复制引用
周弘艳,徐平..菌群-肠-脑轴在酒精性脑损伤中的研究进展[J].中山大学学报（医学科学版）,2026,47(3):419-428,10.基金项目
贵州省教育厅高等学校自然科学研究项目(黔教技[2024]145号) （黔教技[2024]145号）
