中山大学学报（医学科学版）2026，Vol.47Issue(3)：429-439,11.DOI:10.11714/jsysu.med.YX20250166
非侵入性迷走神经刺激治疗脑卒中后上肢运动障碍的研究进展
Research Progress on Non-invasive Vagus Nerve Stimulation for Upper Limb Motor Impairment After Stroke
摘要
Abstract
Upper limb motor impairment is a common sequela of stroke and significantly compromisses patients'activities of daily living and quality of life.Non-invasive vagus nerve stimulation(nVNS),developed from conventional vagus nerve stimulation(VNS),is a safer,more convenient,and cost-effective neuromodulation technique with the adventage of avtive regulation,It has been increasingly applied in clinical practice and neuroscience research,and its therapeutic potential in post-stroke upper limb rehabilitation has been preliminaruly demonstrated.This systematic review comprehensively examines the mechanistic basis and clinical advancements of nVNS in treating upper limb motor dysfunction following stroke,with a particular focus on the International Classification of Functioning,Disability and Health(ICF)framework.From the perspectives of body function,individual activity,and social participation,the rehabilitative effects of nVNS are analyzed in an integrated manner.Specifically,nVNS enhances neural plasticity,mitigates inflammatory responses,and improves cerebral perfusion in ischemic regions by modulating the secretion of neurotransmitters such as norepinephrine,acetylcholine,and γ-aminobutyric acid,thereby promoting neurological recovery at the body function level.Moreover,the synergistic application of nVNS with rehabilitative training has been shown to sustainably improve motor function and activities of daily living,yielding functional benefits that extend to the levels of individual activity and social participation.Building upon this foundation,the present study examines the technical challenges confronting nVNS and proposes future research trajectories focusing on parameter optimization,multimodal neuromodulation integration,and rehabilitation for lower limb dysfunction.These directions aim to facilitate precision personalized therapeutics for stroke patients.关键词
脑卒中/迷走神经刺激/非侵入性/上肢运动障碍/康复Key words
stroke/vagus nerve stimulation/non-invasive/upper limb motor dysfunction/rehabilitation分类
医药卫生引用本文复制引用
谷佳妮,李瑞青..非侵入性迷走神经刺激治疗脑卒中后上肢运动障碍的研究进展[J].中山大学学报（医学科学版）,2026,47(3):429-439,11.基金项目
国家自然科学基金(81503630) （81503630）
河南省自然科学基金(252300420135) （252300420135）
河南省重点研发与推广专项(科技攻关)基金(232102310470) （科技攻关）
河南省科技研发计划联合基金(222301420066) （222301420066）
河南省中医药科学研究专项课题(2023ZXZX1163,2019JDZX2111) （2023ZXZX1163,2019JDZX2111）
