作物学报2026，Vol.52Issue(6)：1604-1617,14.DOI:10.3724/SP.J.1006.2026.51092
小麦籽粒铜含量的全基因组关联分析及候选基因预测
Genome-wide association study and candidate gene prediction of grain copper content in wheat
摘要
Abstract
Copper is an essential trace element in humans,and copper deficiency can compromise health.Wheat is a major staple crop worldwide,and biofortification of wheat grain with copper is a cost-effective strategy to help alleviate dietary copper defi-ciency.However,the genetic basis of grain copper content in wheat remains poorly understood.Here grain copper content was evaluated in 349 wheat accessions,and a genome-wide association study(GWAS)was performed using the Wheat 660K SNP array.In total,775 significant SNPs were identified,mainly on chromosomes 1B,4A,and 7A;among these,56 SNPs were con-sistently detected in four or more replicates.Haplotype analysis indicated that GCuC_Hap_1B and GCuC_Hap_4A are key loci associated with grain copper content and show a significant pyramiding effect.Based on bioinformatics and haplotype analysis,TraesCS1B03G1265400 and TraesCS4A03G0093900 were proposed as candidate genes for regulating grain copper content.These results clarify the genetic architecture of grain copper content in wheat and provide a valuable foundation for developing germ-plasm with elevated grain copper content for wheat quality improvement breeding.关键词
小麦/籽粒铜含量/全基因组关联分析/候选基因分析/品质改良Key words
wheat/grain copper content/genome-wide association study/candidate gene analysis/quality improvement引用本文复制引用
习千辉,徐梓瑗,刘梦梦,王宏艺,郎凯琳,井震海,陈锋,赵磊..小麦籽粒铜含量的全基因组关联分析及候选基因预测[J].作物学报,2026,52(6):1604-1617,14.基金项目
本研究由河南省科技研发计划联合基金项目(242301420132)和河南省高等学校重点科研项目(25A210020)资助.This study was supported by the Henan Provincial Science and Technology Research and Development Program Joint Fund(242301420132)and the Key Scientific Research Projects of Higher Education Institutions in Henan Province(25A210020). （242301420132）
