中国现代医生2026，Vol.64Issue(15)：48-53,79,7.DOI:10.3969/j.issn.1673-9701.2026.15.011
平肝透邪方治疗失眠伴中医烦躁焦虑状态的临床观察与网络药理学及分子对接研究
Clinical observation and network pharmacology and molecular docking study on the treatment of insomnia accompanied by irritation and anxiety state in traditional Chinese medicine by Pinggantouxie formula
摘要
Abstract
Objective To observe the clinical efficacy of Pinggantouxie formula in patients with insomnia accompanied by irritation and anxiety state in traditional Chinese medicine(TCM),and analyze its mechanism by using network pharmacology and molecular docking.Methods 60 patients with insomnia accompanied by irritation and anxiety state in TCM admitted to Rizhao Hospital of Traditional Chinese Medicine from June 2024 to April 2025 were selected as the research subjects,and were treated with Pinggantouxie formula for 4 weeks.Compare the changes in blood routine,liver function,and kidney function of patients before and after treatment to evaluate safety,and compare the changes in scores of Pittsburgh sleep quality index(PSQI),Hamilton anxiety scale(HAMA),and TCM syndrome scale before and after treatment to evaluate effectiveness.Results Compared with before treatment,there were no statistically significant differences in blood routine,liver function and renal function after treatment(P>0.05).After treatment,the scores of PSQI,HAMA and TCM syndrome scale were significantly decreased,with statistically significant differences(P<0.05).Network pharmacology results showed that the key targets of Pinggantouxie formula in the treatment of insomnia included albumin,protein kinase B(PKB,namely AKT1),interleukin(IL)-6,tumor necrosis factor and IL-1β.The key active ingredients were quercetin,jasmone,4-(4'-hydroxybenzyloxy)benzyl methyl ether,suzilactone and N-trans-feruloyltyramine.The key signaling pathways mainly involved neuroactive ligand-receptor interaction,multiple neurodegenerative disease pathways,cyclic adenosine monophosphate signaling pathway,and T helper 17 cell differentiation pathway.Molecular docking results indicated that the key ingredients bound closely to the core targets.Among them,suzilactone and quercetin exhibited the strongest binding activity with AKT1.Conclusion Pinggantouxie formula can effectively treat insomnia accompanied by TCM irritability and anxiety state,and exerts its therapeutic effects through a multi-component,multi-target and multi-pathway mechanism.关键词
失眠/中医烦躁焦虑状态/平肝透邪方/网络药理学Key words
Insomnia/Irritation and anxiety state in TCM/Pinggantouxie formula/Network pharmacology分类
医药卫生引用本文复制引用
刘呈祥,宫庆东,徐星华,李艳君,刘雪梅,牟磊..平肝透邪方治疗失眠伴中医烦躁焦虑状态的临床观察与网络药理学及分子对接研究[J].中国现代医生,2026,64(15):48-53,79,7.基金项目
山东省日照市中医药科技项目(RZY2023C03) （RZY2023C03）
